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Table 2 Table lists the gene symbol and the KEGG pathway of selected genes

From: Improving knowledge on the activation of bone marrow fibroblasts in MGUS and MM disease through the automatic extraction of genes via a nonnegative matrix factorization approach on gene expression profiles

Gene symbol

Pathway name

Gene symbol

Pathway name

TNF

T cell receptor signaling pathway, osteoclast differentiation, natural killer cell mediated cytotoxicity, Fc epsilon RI signaling pathway, TGF-beta signaling pathway, amyotrophic lateral sclerosis (ALS), malaria

FYN

T cell receptor signaling pathway, osteoclast differentiation, natural killer cell mediated cytotoxicity, Fc epsilon RI signaling pathway, axon guidance, focal adhesion

PPP3CB

T cell receptor signaling pathway, osteoclast differentiation, natural killer cell mediated cytotoxicity, axon guidance, amyotrophic lateral sclerosis (ALS)

NFATC1

T cell receptor signaling pathway, osteoclast differentiation, natural killer cell mediated cytotoxicity, axon guidance

LCP2

T-cell receptor signaling pathway, osteoclast differentiation, natural Killer cell mediated cytoxicity, Fc epsilon RI signaling pathway

EGF

Pathway in cancer, focal adhesion, endometrial cancer

HGF

Pathway in cancer, malaria, focal adhesion

TGFB3

Pathway in cancer, malaria, TGF-beta signaling pathway

LAT

T-cell receptor signaling pathway, natural Killer cell mediated cytoxicity, Fc epsilon RI signaling pathway

CASP9

Pathways in cancer, amyotrophic lateral sclerosis (ALS), endometrial cancer

COMP

TGF-beta signaling pathway, focal adhesion, malaria

GAB2

Osteoclast differentiation, Fc epsilon RI signaling pathway

CRK

Pathway in cancer, focal adhesion

APC2

Pathway in cancer, endometrial cancer

BMP4

Pathway in cancer, TGF-beta signaling pathway

SPI1

Pathway in cancer, osteoclast differentiation

PDPK1

Focal adhesion, endometrial cancer

FCGR3B

Osteoclast differentiation, natural killer cell mediated cytoxicity

CD3E

T cell receptor signaling pathway

CD28

T cell receptor signaling pathway

CSF2RA

Pathways in cancer

SLIT2

Axon guidance

ID2

TGF-beta signaling pathway

E2F5

TGF-beta signaling pathway

PTPN11

Cytotoxicity mediated by killer cells

FZD2

Pathways in cancer

ACTN1

Focal adhesion

CFL1

Axon guide

RHOD

Axon guide

MAP3K5

Amyotrophic lateral sclerosis (ALS)

  1. Only 14% of the total number of genes has been selected with the WebGestalt tool