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Fig. 9 | Journal of Translational Medicine

Fig. 9

From: Improving knowledge on the activation of bone marrow fibroblasts in MGUS and MM disease through the automatic extraction of genes via a nonnegative matrix factorization approach on gene expression profiles

Fig. 9

Functional network of different pathways genes. The functional network created by the genes in the 11 pathways selected and belonging to the subset of uncommon metaMM. The CAFs have acquired additional properties from those belonging to the common metaMGUS subset. In particular, the 30 selected genes regulate processes such as: epithelial–mesenchymal transition (EMT), immortalization, inhibition of apoptosis, changes in glucose metabolism and the mediation of the immune response. The phenotype acquired by fibroblasts shows properties that include homeostatic regulation and hormonal control of bone turnover (PPP3CB, FYN, NFATC1, RHOD, SLIT2, CFL1) and also mediate signals with specific receptors, growth factors and cytokines

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Journal of Translational Medicine

ISSN: 1479-5876

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