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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Regulatory network of circRNA–miRNA–mRNA contributes to the histological classification and disease progression in gastric cancer

Fig. 5

Up-regulated mRNA expression levels of target genes mediated by circHIPK3-miR-124/miR-29b axes revealed by Oncomine analyses in 80 GC cases. a Over-expression of circHIPK3 increased the mRNA expression of COL4A1, COL1A1 and CDK6. b Knockdown of circHIPK3 inhibits mRNA expression of COL4A1, COL1A1 and CDK6. c–e Expressions of COL1A1, COL4A1 and CDK6 were found to be upregulated comparing with normal gastric tissues, respectively. f–h ROC curve revealed clinical value of COL1A1 and COL4A1 but not CDK6 in the screening of GC. *P < 0.05, **P < 0.01, ***P < 0.001

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Journal of Translational Medicine

ISSN: 1479-5876

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