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Table 3 UGT1A1 polymorphisms and clinical variables of multivariate analysis for non-CR risk in AML

From: Influence of UGT1A1 polymorphisms on the outcome of acute myeloid leukemia patients treated with cytarabine-base regimens

Variables in the model Non-CR risk after two courses of induction Non-CR risk after the first course of induction
OR (95% CI) P value OR (95% CI) P value
UGT1A1 *28/− or *6/ 0.547 (0.375–0.797) 0.002 0.622 (0.446–0.868) 0.005
Risk stratification groups   2.5 × 10−6   0.021
 Low vs intermediate 0.457 (0.269–0.776) 0.004 0.678 (0.455–1.011) 0.056
 High vs intermediate 2.045 (1.331–3.140) 0.001 1.365 (0.880–2.116) 0.164
WBC count, × 109/l 1.004 (1.001–1.007) 0.008 1.005 (1.001–1.008) 0.011
Age, years 1.014 (1.001–1.028) 0.036 1.005 (0.993–1.017) 0.448
  1. WBC white blood cell