Fig. 4

Transmission electron microscopy (TEM) of the platelets at different storage durations and temperatures. Magnification, ×12,000: fresh platelets (a), platelets stored at 22 °C for 2 days (b), platelets stored at 4 °C for 2 days (c), platelets stored at 22 °C for 5 days (d), and platelets stored at 4 °C for 5 days (e). Aged platelets showed morphologic changes including changes in alpha granule and cell shape (d, e), and refrigerated platelets showed damaged cell membrane resulting in release of granules and cell organelles (c, e)