Markera | Median levels and 25–75% percentile (pg/mL) | p-value | ||||
---|---|---|---|---|---|---|
ATB (n = 28) | LTBI (n = 34) | CON (n = 26) | ATB vs CON | LTBI vs CON | ATB vs LTBI | |
TB-antigen stimulated | ||||||
 IFN-γ | 77.6 (29.4 to 134.7) | 30.6 (15.5 to 77.5) | − 1.9 (− 20.4 to 18.3) | < 0.0001 | < 0.0001 | 0.1424 |
 IP-10 | 10,821 (4405 to 18,052) | 6221 (4650 to 10,956) | 6.5 (− 86.1 to 215.1) | < 0.0001 | < 0.0001 | 0.0994 |
 IL-2 | 116.8 (31.1 to 270.6) | 137.1 (51.7 to 261.4) | − 0.3 (− 4.1 to 4.5) | < 0.0001 | < 0.0001 | 0.6559 |
 IL-1Ra | 1342 (331.4 to 2778) | 881.6 (453.0 to 2134) | -23.1 (− 186.3 to 242.5) | < 0.0001 | < 0.0001 | 0.2524 |
 MCP-1 | 9848 (203.2 to 2640) | 1610 (− 5.6 to 3526) | − 26.2 (− 300.4 to 159) | < 0.0001 | < 0.0001 | 0.7718 |
 IL-15 | 2.0 (− 1.5 to 10.4) | 3.6 (− 4.0 to 12.7) | − 2.0 (− 10 to 1.2) | 0.0018 | 0.0062 | 0.5146 |
 PDGF | 51.68 (1.330 to 170.0) | − 41.67 (− 192.5 to 47.75) | 111.0 (− 35.15 to 303.4) | 0.4832 | 0.011 | 0.0165 |
Unstimulated | ||||||
 VEGF | 225.1 (144.3 to 350.2) | 127.3 (86.58 to 195.9) | 91.89 (50.18 to 130.1) | < 0.0001 | 0.022 | 0.003 |
 MCP-1 | 3460 (1651 to 4262) | 1471 (636.4 to 4000) | 729.5 (380.9 to 1404) | < 0.0001 | 0.0105 | 0.1356 |
 IL-12 (p70) | 57.39 (32.79 to 89.25) | 34.05 (24.52 to 55.21) | 29.19 (15.74 to 35.83) | < 0.0001 | 0.0354 | 0.0344 |
 MIP-1b | 3164 (1629 to 9066) | 3266 (993 to 6318) | 1354 (750 to 2240) | 0.0005 | 0.0115 | 0.4838 |
 Rantes | 6575 (3309 to 9687) | 3448 (2255 to 7981) | 1905 (1608 to 2893) | < 0.0001 | 0.0002 | 0.0649 |
 IFN-γ | 129.5 (68.27 to 216.6) | 95.21 (48.73 to 150.7) | 53.32 (31.47 to 110.7) | 0.0012 | 0.0305 | 0.0298 |
 IP-10 | 2025 (1460 to 2786) | 1138 (473.8 to 2571) | 671.2 (446.9 to 1166) | < 0.0001 | 0.0746 | 0.0147 |
 IL-9 | 70.08 (44.87 to 139.1) | 51.1 (31.56 to 94.33) | 33.66 (21.72 to 59.4) | 0.0005 | 0.0771 | 0.0937 |
 TNF-α | 473 (161.2 to 1007) | 218.6 (90.05 to 745) | 190.5 (57.65 to 373) | 0.0112 | 0.224 | 0.091 |
 FGF | 54.44 (44.94 to 66.6) | 41.76 (26.95 to 73.65) | 36.7 (23.25 to 61.72) | 0.0267 | 0.2894 | 0.0501 |