Skip to main content

Table 2 TB-antigen stimulated and unstimulated levels of differentially expressed cytokines as measured with the bio-plex assay

From: Screening and identification of a six-cytokine biosignature for detecting TB infection and discriminating active from latent TB

Markera

Median levels and 25–75% percentile (pg/mL)

p-value

ATB (n = 28)

LTBI (n = 34)

CON (n = 26)

ATB vs CON

LTBI vs CON

ATB vs LTBI

TB-antigen stimulated

 IFN-γ

77.6 (29.4 to 134.7)

30.6 (15.5 to 77.5)

− 1.9 (− 20.4 to 18.3)

< 0.0001

< 0.0001

0.1424

 IP-10

10,821 (4405 to 18,052)

6221 (4650 to 10,956)

6.5 (− 86.1 to 215.1)

< 0.0001

< 0.0001

0.0994

 IL-2

116.8 (31.1 to 270.6)

137.1 (51.7 to 261.4)

− 0.3 (− 4.1 to 4.5)

< 0.0001

< 0.0001

0.6559

 IL-1Ra

1342 (331.4 to 2778)

881.6 (453.0 to 2134)

-23.1 (− 186.3 to 242.5)

< 0.0001

< 0.0001

0.2524

 MCP-1

9848 (203.2 to 2640)

1610 (− 5.6 to 3526)

− 26.2 (− 300.4 to 159)

< 0.0001

< 0.0001

0.7718

 IL-15

2.0 (− 1.5 to 10.4)

3.6 (− 4.0 to 12.7)

− 2.0 (− 10 to 1.2)

0.0018

0.0062

0.5146

 PDGF

51.68 (1.330 to 170.0)

− 41.67 (− 192.5 to 47.75)

111.0 (− 35.15 to 303.4)

0.4832

0.011

0.0165

Unstimulated

 VEGF

225.1 (144.3 to 350.2)

127.3 (86.58 to 195.9)

91.89 (50.18 to 130.1)

< 0.0001

0.022

0.003

 MCP-1

3460 (1651 to 4262)

1471 (636.4 to 4000)

729.5 (380.9 to 1404)

< 0.0001

0.0105

0.1356

 IL-12 (p70)

57.39 (32.79 to 89.25)

34.05 (24.52 to 55.21)

29.19 (15.74 to 35.83)

< 0.0001

0.0354

0.0344

 MIP-1b

3164 (1629 to 9066)

3266 (993 to 6318)

1354 (750 to 2240)

0.0005

0.0115

0.4838

 Rantes

6575 (3309 to 9687)

3448 (2255 to 7981)

1905 (1608 to 2893)

< 0.0001

0.0002

0.0649

 IFN-γ

129.5 (68.27 to 216.6)

95.21 (48.73 to 150.7)

53.32 (31.47 to 110.7)

0.0012

0.0305

0.0298

 IP-10

2025 (1460 to 2786)

1138 (473.8 to 2571)

671.2 (446.9 to 1166)

< 0.0001

0.0746

0.0147

 IL-9

70.08 (44.87 to 139.1)

51.1 (31.56 to 94.33)

33.66 (21.72 to 59.4)

0.0005

0.0771

0.0937

 TNF-α

473 (161.2 to 1007)

218.6 (90.05 to 745)

190.5 (57.65 to 373)

0.0112

0.224

0.091

 FGF

54.44 (44.94 to 66.6)

41.76 (26.95 to 73.65)

36.7 (23.25 to 61.72)

0.0267

0.2894

0.0501

  1. ATB active tuberculosis, LTBI latent tuberculosis infection, CON TB uninfected subjects
  2. aOnly cytokines that were differentially expressed between any two groups of the ATB, LTBI, and CON are listed