Table 1 Clinicopathological and immune characteristics of CRC patients based on MMR status
Characteristics | pMMR | dMMR | r | p value |
|---|---|---|---|---|
Number of cases (n, %) | ||||
Age at diagnosis (years) | 0.194 | < 0.001 | ||
 < 60 | 80 (47.9) | 110 (67.5) |  |  |
 ≥ 60 | 87 (52.1) | 53 (32.5) |  |  |
Gender | Â | 0.24 | ||
 Male | 96 (57.5) | 104 (63.8) |  |  |
 Female | 71 (42.5) | 59 (36.2) |  |  |
Primary tumor site | 0.264 | < 0.001 | ||
 Left colon | 81 (48.5) | 41 (25.2) |  |  |
 Right colon | 47 (28.1) | 86 (52.8) |  |  |
 Rectum | 39 (23.4) | 36 (22.1) |  |  |
Stage (7th AJCC) | Â | 0.965 | ||
 I | 27 (16.2) | 26 (16.0) |  |  |
 II | 89 (53.3) | 85 (52.1) |  |  |
 III | 42 (25.1) | 41 (25.2) |  |  |
 IV | 9 (5.4) | 11 (6.7) |  |  |
Tumor stage | 0.193 | 0.012 | ||
 T1 | 8 (4.8) | 5 (3.1) |  |  |
 T2 | 25 (15.0) | 24 (14.7) |  |  |
 T3 | 118 (70.7) | 95 (58.3) |  |  |
 T4a | 11 (6.6) | 27 (16.6) |  |  |
 T4b | 5 (3.0) | 12 (7.4) |  |  |
Node stage | Â | 0.819 | ||
 Negative | 119 (71.3) | 118 (72.4) |  |  |
 Positive | 48 (28.7) | 45 (27.6) |  |  |
Negative lymph nodes | 0.179 | 0.001 | ||
 Low (< 14) | 102 (61.1) | 70 (42.9) |  |  |
 High (≥ 14) | 65 (38.9) | 93 (57.1) |  |  |
Tumor histological grade | 0.212 | 0.001 | ||
 Well-differentiated | 2 (1.2) | 1 (0.6) |  |  |
 Moderately differentiated | 109 (65.3) | 77 (47.2) |  |  |
 Poorly differentiated | 27 (16.2) | 27 (16.6) |  |  |
 Mucinous | 29 (17.4) | 58 (35.6) |  |  |
Nerve invasion | 0.12 | 0.029 | ||
 No | 142 (85.0) | 151 (92.6) |  |  |
 Yes | 25 (15.0) | 12 (7.4) |  |  |
Vascular invasion | 0.123 | 0.025 | ||
 No | 143 (85.6) | 152 (93.3) |  |  |
 Yes | 24 (14.4) | 11 (6.7) |  |  |
MHC class I expression | 0.454 | < 0.001 | ||
 Low | 12 (7.2) | 88 (54.0) |  |  |
 High | 155 (92.8) | 75 (46.0) |  |  |
CD3 expression | 0.026 | 0.661 | ||
 Low | 66 (43.4) | 63 (46.0) |  |  |
 High | 86 (56.6) | 74 (54.0) |  |  |
CD8 expression | 0.156 | 0.009 | ||
 Low | 83 (59.3) | 57 (43.5) |  |  |
 High | 57 (40.7) | 74 (56.5) |  |  |
CD56 expression | 0.228 | < 0.001 | ||
 Low | 41 (24.7) | 75 (47.2) |  |  |
 High | 125 (75.3) | 84 (52.8) |  |  |
CD4 expression | 0.2 | < 0.001 | ||
 Low | 49 (30.1) | 78 (50.0) |  |  |
 High | 114 (69.9) | 78 (50.0) |  |  |
PD-1 expression | 0.043 | 0.483 | ||
 Low | 62 (46.3) | 55 (42.0) |  |  |
 High | 72 (53.7) | 76 (58.0) |  |  |
PD-L1 expression | 0.133 | 0.015 | ||
 Negative | 77 (46.1) | 97 (59.5) |  |  |
 Positive | 90 (53.9) | 66 (40.5) |  |  |