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Table 1 Clinicopathological and immune characteristics of CRC patients based on MMR status

From: Comparison of immunological characteristics between paired mismatch repair-proficient and -deficient colorectal cancer patients

Characteristics pMMR dMMR r p value
Number of cases (n, %)
Age at diagnosis (years) 0.194 < 0.001
 < 60 80 (47.9) 110 (67.5)   
 ≥ 60 87 (52.1) 53 (32.5)   
Gender   0.24
 Male 96 (57.5) 104 (63.8)   
 Female 71 (42.5) 59 (36.2)   
Primary tumor site 0.264 < 0.001
 Left colon 81 (48.5) 41 (25.2)   
 Right colon 47 (28.1) 86 (52.8)   
 Rectum 39 (23.4) 36 (22.1)   
Stage (7th AJCC)   0.965
 I 27 (16.2) 26 (16.0)   
 II 89 (53.3) 85 (52.1)   
 III 42 (25.1) 41 (25.2)   
 IV 9 (5.4) 11 (6.7)   
Tumor stage 0.193 0.012
 T1 8 (4.8) 5 (3.1)   
 T2 25 (15.0) 24 (14.7)   
 T3 118 (70.7) 95 (58.3)   
 T4a 11 (6.6) 27 (16.6)   
 T4b 5 (3.0) 12 (7.4)   
Node stage   0.819
 Negative 119 (71.3) 118 (72.4)   
 Positive 48 (28.7) 45 (27.6)   
Negative lymph nodes 0.179 0.001
 Low (< 14) 102 (61.1) 70 (42.9)   
 High (≥ 14) 65 (38.9) 93 (57.1)   
Tumor histological grade 0.212 0.001
 Well-differentiated 2 (1.2) 1 (0.6)   
 Moderately differentiated 109 (65.3) 77 (47.2)   
 Poorly differentiated 27 (16.2) 27 (16.6)   
 Mucinous 29 (17.4) 58 (35.6)   
Nerve invasion 0.12 0.029
 No 142 (85.0) 151 (92.6)   
 Yes 25 (15.0) 12 (7.4)   
Vascular invasion 0.123 0.025
 No 143 (85.6) 152 (93.3)   
 Yes 24 (14.4) 11 (6.7)   
MHC class I expression 0.454 < 0.001
 Low 12 (7.2) 88 (54.0)   
 High 155 (92.8) 75 (46.0)   
CD3 expression 0.026 0.661
 Low 66 (43.4) 63 (46.0)   
 High 86 (56.6) 74 (54.0)   
CD8 expression 0.156 0.009
 Low 83 (59.3) 57 (43.5)   
 High 57 (40.7) 74 (56.5)   
CD56 expression 0.228 < 0.001
 Low 41 (24.7) 75 (47.2)   
 High 125 (75.3) 84 (52.8)   
CD4 expression 0.2 < 0.001
 Low 49 (30.1) 78 (50.0)   
 High 114 (69.9) 78 (50.0)   
PD-1 expression 0.043 0.483
 Low 62 (46.3) 55 (42.0)   
 High 72 (53.7) 76 (58.0)   
PD-L1 expression 0.133 0.015
 Negative 77 (46.1) 97 (59.5)   
 Positive 90 (53.9) 66 (40.5)   
  1. r: contingency coefficient