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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Polyethylene glycol-conjugated HER2-targeted peptides as a nuclear imaging probe for HER2-overexpressed gastric cancer detection in vivo

Fig. 7

The nuclear imaging agent of 111In-DTPA-AHNP-PEG for gastric tumor detection in vivo. a The gastric tumor nuclear imaging analysis in NCI-N87-induced xenograft model. The 111In-DTPA, 111In-DTPA-AHNP, 111In-DTPA-PEG, and 111In-DTPA-AHNP-PEG were intravenous injected into mice for 1, 4, 24, 48 h and observed by using nanoSPECT/CT. b The oval-shaped labeling displayed the tumor site of gastric tumor xenograft mice for imaging quantification. Data are presented as mean ± SEM (n ≥ 3). *P < 0.05, versus 111In-DTPA, 111In-DTPA-AHNP, or 111In-DTPA-PEG group. c The blocking study of 111In-DTPA-AHNP-PEG in NIC-N87 tumor xenograft mice. After tumor xenograft animals were intravenous injected AHNP-PEG (0, 10, 50 mg/kg) for 4 h, 111In-DTPA-AHNP-PEG (1 mCi/per mouse) was intravenous injected into all mice for 24 and 48 h and observed by using nanoSPECT/CT. d The oval-shaped labeling displayed the tumor site of gastric tumor xenograft mice for imaging quantification. Data are presented as mean ± SEM (n ≥ 3). *P < 0.05, versus 10 mg/kg AHNP-PEG group, #P < 0.05, versus 0 mg/kg AHNP-PEG group

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