Fig. 7

The nuclear imaging agent of ¹¹¹In-DTPA-AHNP-PEG for gastric tumor detection in vivo. a The gastric tumor nuclear imaging analysis in NCI-N87-induced xenograft model. The ¹¹¹In-DTPA, ¹¹¹In-DTPA-AHNP, ¹¹¹In-DTPA-PEG, and ¹¹¹In-DTPA-AHNP-PEG were intravenous injected into mice for 1, 4, 24, 48 h and observed by using nanoSPECT/CT. b The oval-shaped labeling displayed the tumor site of gastric tumor xenograft mice for imaging quantification. Data are presented as mean ± SEM (n ≥ 3). *P < 0.05, versus ¹¹¹In-DTPA, ¹¹¹In-DTPA-AHNP, or ¹¹¹In-DTPA-PEG group. c The blocking study of ¹¹¹In-DTPA-AHNP-PEG in NIC-N87 tumor xenograft mice. After tumor xenograft animals were intravenous injected AHNP-PEG (0, 10, 50 mg/kg) for 4 h, ¹¹¹In-DTPA-AHNP-PEG (1 mCi/per mouse) was intravenous injected into all mice for 24 and 48 h and observed by using nanoSPECT/CT. d The oval-shaped labeling displayed the tumor site of gastric tumor xenograft mice for imaging quantification. Data are presented as mean ± SEM (n ≥ 3). *P < 0.05, versus 10 mg/kg AHNP-PEG group, ^#P < 0.05, versus 0 mg/kg AHNP-PEG group