Fig. 2

Differentially expressed genes associated with response to TG tablets. a Heat map showing hierarchical clustering of mRNAs, whose expression changes were more than 1.5-fold in the comparison between the responder and non-responder groups. In clustering analysis, up- and down-regulated genes are colored in red and green, respectively. b, c Top 30 of GO items and KEGG pathways enriched by the differentially expressed genes in the comparison between the responder and non-responder groups. GO items and KEGG pathways with red marks were significantly associated with RA development and progression