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Table 4 Incidence, and hazard ratio of bipolar disorders between patients with hepatitis infection with and without treatment

From: Association of viral hepatitis and bipolar disorder: a nationwide population-based study

Variables

N

Event

PY

%

Crude HR (95% CI)

Adjusted HR† (95% CI)

Hepatitis infection

 Without treatment

44,461

54

262,819

2.05

1.00

1.00

Only HBV treatment

 Lamivudine, telbivudine, adefovir, tenofovir, and entecavir

2151

2

11,820

1.69

0.82 (0.20, 3.36)

0.85 (0.21, 3.53)

Only HCV treatment

 Ribavirin, interferon

1081

2

6623

3.02

1.48 (0.36, 6.05)

1.29 (0.31, 5.37)

Both HBV&HCV treatment

522

0

3634

0.00

–

–

  1. PY Person-years,  % rate, per 10,000 person-years
  2. † Multivariable analysis including age, sex, and comorbidities of cirrhosis, hypertension, hyperlipidemia, asthma, coronary artery disease, alcohol-related illness, anxiety, and major depressive disorders