Table 5 Pathways in common in all breast cancer subtypes and specific for each subtype as derived from the proposed network approach

Assembly of RNA polymerase II complex

Cell cycle regulation by BTG family proteins

Antioxidant action of vitamin C

Actin cytoskeleton signaling

Aryl Hydrocarbon Receptor Signaling

Axonal guidance signaling

Chemokine signaling

Germ cell-sertoli cell junction signaling

Adrenergic signaling

eNOS signaling

Coagulation system

Chondroitin sulfate biosynthesis

HMGB1 signaling

Breast cancer regulation by Stathmin1

Fatty acid oxidation I

Colorectal cancer metastasis signaling

chondroitin sulfate biosynthesis (late stages)

IL-6 signaling

cAMP-mediated signaling

Gluconeogenesis I

EIF2 signaling

Ephrin B signaling

Linolenate biosynthesis II (animals)

Cardiac hypertrophy signaling

Glycolysis I

Ethanol degradation II

Granulocyte adhesion and diapedesis

Antioxidant action of vitamin C

Caveolar-mediated endocytosis signaling

IL-1 signaling

Ethanol Degradation IV

Heparan sulfate biosynthesis

Germ cell-sertoli cell junction signaling

Corticotropin Releasing Hormone Signaling

Mitochondrial Dysfunction

Extrinsic prothrombin activation pathway

Heparan sulfate biosynthesis (late stages)

HMGB1_Signaling

CREB signaling in neurons

mTOR signaling

Fatty acid-oxidation

LXR/RXR activation

IL-6 signaling

DNA damage-induced 14–3–3 signaling

Phenylalanine Degradation IV (Mammalian, via Side Chain)

HIF1 signaling

Pancreatic adenocarcinoma signaling

Linolenate biosynthesis II (animals)

Endothelin-1 signaling

Phototransduction pathway

Histamine degradation

Pregnenolone biosynthesis

Gap junction signaling

PI3K/AKT signaling

Noradrenaline and adrenaline degradation

Regulation of cellular mechanics by calpain protease

GDNF family ligand–receptor interactions

Oxidative ethanol degradation III

Semaphorin signaling in neurons

Glycine betaine degradation

Putrescine degradation III

Superoxide radicals degradation

Glycogen degradation II

Tryptophan degradation X (mammalian, via tryptamine)

Induction of apoptosis by HIV1

Leptin signaling in obesity

Macropinocytosis signaling

NAD biosynthesis II (from tryptophan)

Ovarian cancer signaling

Relaxin signaling

RhoGDI signaling

Role of IL-17A in psoriasis

Role of tissue factor in cancer

Sperm motility

Synaptic long term depression

tRNA splicing

Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde

TWEAK Signaling