Fig. 2

Drug target pathway network. In de-regulated pathway network, the activity of pathway interactions (network efficiency, (NE)) is calculated. 1 and 4 Inhibition of an individual pathway and its interactions. A new-NE (nNE) is calculated. 2 and 5 If nNE < NE the inhibited pathway could be a potential drug target. 3 and 6 integration of drug-pathway associations. 7 nNE is calculated inhibiting two pathways