A strategy for designing voriconazole dosage regimens to prevent invasive pulmonary aspergillosis based on a cellular pharmacokinetics/pharmacodynamics model

Table 2 The probability of target attainment values at a certain minimum inhibitory concentration and the cumulative fraction of response values for A. fumigatus at different dosage regimens

Dosage regimens	Probability of target attainment (%) at different minimum inhibitory concentrations										CFR (%)
Dosage regimens	0.03125 mg/L	0.0625 mg/L	0.125 mg/L	0.25 mg/L	0.5 mg/L	1 mg/L	2 mg/L	4 mg/L	8 mg/L	16 mg/L	CFR (%)
100 mg/12 h, p.o.	99.25	96.35	85.27	63.9	36.39	14.92	4.14	0.72	0.099	0.006	84.45
200 mg/12 h, p.o.	99.65	98.21	92.94	80.01	58.78	34.15	15.28	4.92	1.15	0.21	91.48
300 mg/12 h, p.o.	99.98	99.67	98.03	92.25	77.55	54.15	29.07	11.35	3.07	0.61	96.19

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