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Table 2 The probability of target attainment values at a certain minimum inhibitory concentration and the cumulative fraction of response values for A. fumigatus at different dosage regimens

From: A strategy for designing voriconazole dosage regimens to prevent invasive pulmonary aspergillosis based on a cellular pharmacokinetics/pharmacodynamics model

Dosage regimens Probability of target attainment (%) at different minimum inhibitory concentrations CFR (%)
0.03125 mg/L 0.0625 mg/L 0.125 mg/L 0.25 mg/L 0.5 mg/L 1 mg/L 2 mg/L 4 mg/L 8 mg/L 16 mg/L
100 mg/12 h, p.o. 99.25 96.35 85.27 63.9 36.39 14.92 4.14 0.72 0.099 0.006 84.45
200 mg/12 h, p.o. 99.65 98.21 92.94 80.01 58.78 34.15 15.28 4.92 1.15 0.21 91.48
300 mg/12 h, p.o. 99.98 99.67 98.03 92.25 77.55 54.15 29.07 11.35 3.07 0.61 96.19
  1. CFR cumulative fraction of response