Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2 G2019S -Parkinson’s disease

Table 1 Epidemiological characteristics of the cohorts

Group	N	Gender		Age (years)
Group	N	Male	Female	Range	Mean	SEM
NM-LRRK2^G2019S	6	3 (50%)	3 (50%)	34–61	46.67	4.04
PD-LRRK2^G2019S	7	3 (42.85%)	4 (57.15%)	44–71	60.57	3.15
Control	8	3 (37.50%)	5 (62.50%)	41–69	56.00	3.63

Epidemiological data of the studied cohorts at the time of skin biopsy. No significant differences were found in age or gender between groups
NM-LRRK2^G2019S: Non-manifesting LRRK2^G2019S-mutation carriers; PD-LRRK2^G2019S: patients with LRRK2^G2019S-mutation and clinically manifest PD; N: Number of cases enrolled; SEM: Standard error of the mean

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