Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711

Table 1 Potency of MIV-711 against various cathepsin enzymes

Species	Recombinant enzyme	K_i (nmol/L)	95% CI (nmol/L)	n
Human	Cathepsin K	0.98	0.88–1.09	40
	Cathepsin B	1300		1
	Cathepsin L	1700	1500–1900	39
	Cathepsin F	2800		1
	Cathepsin V	4000		1
	Cathepsin H	> 10,000		1
	Cathepsin S	15,700	12,500–19,800	39
Dog	Cathepsin K	1.5	0.75–2.9	4
Rabbit	Cathepsin K	3.3^a	0.9–12	4
Guinea pig	Cathepsin K	9.8	8.1–12	2
Rat	Cathepsin K	240^a	180–320	3
Mouse	Cathepsin K	1000^a	680–1500	3

ISSN: 1479-5876