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Table 2 Univariate and multivariate analyses of variables for overall survival in AML patients

From: Dysregulation of miR-200s clusters as potential prognostic biomarkers in acute myeloid leukemia

Variables

Complete remission

Overall survival

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

OR (95% CI)

P

OR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

miR-200a

0.548 (0.242–1.244)

0.150

1.029 (0.285–3.722)

0.965

0.662 (0.415–1.022)

0.082

1.425 (0.651–3.120)

0.376

miR-200b

0.384 (0.167–0.885)

0.025

0.823 (0.199–3.401)

0.788

0.511 (0.319–0.819)

0.005

0.524 (0.305–0.902)

0.020

miR-429

0.384 (0.167–0.885)

0.025

0.331 (0.128–0.858)

0.023

0.558 (0.350–0.891)

0.015

0.820 (0.325–2.073)

0.675

miR-200c

0.384 (0.167–0.885)

0.025

0.977 (0.149–6.400)

0.981

0.606 (0.380–0.965)

0.035

0.649 (0.190–2.217)

0.491

miR-141

0.460 (0.201–1.050)

0.065

0.594 (0.192–1.833)

0.364

0.695 (0.437–1.104)

0.123

1.152 (0.582–2.279)

0.684

Age

4.229 (1.742–10.266)

0.001

4.555 (1.715–12.095)

0.002

2.046 (1.282–3.266)

0.003

1.732 (1.033–2.902)

0.037

WBC

2.367 (1.015–5.520)

0.046

1.846 (0.715–4.767)

0.206

2.002 (1.253–3.199)

0.004

1.560 (0.925–2.629)

0.095

Karyotype

3.108 (1.338–7.220)

0.008

2.862 (1.164–7.042)

0.022

1.875 (1.295–2.715)

0.001

1.874 (1.210–2.902)

0.005

CEBPA mutations

0.526 (0.160–1.731)

0.290

  

0.870 (0.413–1.829)

0.713

  

NPM1 mutations

0.833 (0.207–3.358)

0.798

  

1.200 (0.516–2.793)

0.672

  

FLT3-ITD mutations

0.833 (0.207–3.358)

0.798

  

0.935 (0.403–2.170)

0.876

  

C-KIT mutations

0.673 (0.041–11.150)

0.783

  

0.479 (0.066–3.458)

0.465

  

N/K-RAS mutations

3.048 (0.605–15.343)

0.177

  

1.311 (0.621–2.770)

0.478

  

IDH1/2 mutations

Undetermined

0.999

  

4.671 (1.637–13.326)

0.004

6.662 (1.757–25.268)

0.005

DNMT3A mutations

1.391 (0.240–8.057)

0.712

  

1.590 (0.634–3.987)

0.323

  

U2AF1 mutations

Undetermined

0.999

  

2.791 (0.987–7.890)

0.053

5.130 (1.714–15.355)

0.003

SRSF2 mutations

Undetermined

0.999

  

1.934 (0.693–5.400)

0.208

  

SETBP1 mutations

0.673 (0.041–11.150)

0.783

  

0.637 (0.088–4.613)

0.656

  
  1. OR odd ratio, HR hazard ratio, CI confidence interval. Variables including miR-200s cluster expression (Low vs. High), age (≤ 60 vs. > 60 years), WBC (≥ 30 × 109 vs. < 30 × 109/L), karyotype (favorable vs. intermediate vs. poor), and gene mutations (mutant vs. wild-type). Multivariate analysis includes variables with P < 0.200 in univariate analysis
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Journal of Translational Medicine

ISSN: 1479-5876

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