Table 1 The clinical characteristics of patients
Clinical characteristics | Patients (n = 1720) | Crizotinib treated (n = 66) | ||
|---|---|---|---|---|
ALK positive (n = 187) | ALK negative (n = 1533) | p valuea | ||
Age (years), median (range) | 51 (22–84) | 69 (20–92) | < 0.001 | 54 (33–71) |
Gender | 0.646 | Â | ||
 Male | 114 | 961 |  | 42 |
 Female | 73 | 572 | 24 | |
Smoking status | < 0.001 |  | ||
 Yes | 13 | 532 |  | 4 |
 No | 174 | 1001 | 62 | |
Stage | < 0.001 |  | ||
 I–IIIa | 16 | 498 |  | 0 |
 IIIb–IV | 171 | 1035 | 66 | |
Histology | 0.121 | Â | ||
 Adenocarcinoma | 157 | 1213 |  | 65 |
 Non-adenocarcinoma | 30 | 320 | 1 | |
Specimen type | 0.375 | Â | ||
 Fine needle aspirate | 123 | 928 |  | 66 |
 Surgical specimens | 56 | 524 | 0 | |
 Cytology specimens | 8 | 81 | 0 | |
EGFR status |  | < 0.001 |  | |
 Wild type | 119 | 472 |  | 50 |
 Mutation | 13 | 532 | 0 | |
 Unknown | 55 | 529 | 16 | |