Fig. 1
From: The physiological role of Motin family and its dysregulation in tumorigenesis
Schematic illustrations of the domain structures and motifs of the Motin protein family and YAP1-2γ/TAZ. Because of the alternative splicing, AMOT-p80 is an N-terminal truncated protein of AMOT-p130. The N-terminal domain of AMOT-p130 contains LPTY motif and two PPEY motifs, which are required for YAP1-binding. Except for the Angiostatin-binding domain, AMOTL1 and AMOTL2 share sequence identity with AMOT-p130. In addition, all members of Motin possess a Bin/Amphiphysin/Rvs (BAR) domain. Prominent regions of YAP1-2γ/TAZ include WW domain(s), TEAD transcription factor-binding domain, transcriptional activation domain (TAD) and post synaptic density protein (PSD95) binding domain (PDZ BD). WW domains are required by AMOTs binding