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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: CD109 and squamous cell carcinoma

Fig. 3

CD109 and EGFR/STAT3 signaling. CD109 facilitates EGFR signaling. The dimerized EGFR receptors phosphorylate c-Src, which in turn phosphorylates STAT3. CD109 may also activates STAT3 through phosphorylation of JAK2, then promote SCC cell growth, differentiation, and angiogenesis

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