Dexmedetomidine attenuates lung apoptosis induced by renal ischemia–reperfusion injury through α2AR/PI3K/Akt pathway

Table 1 Results of arterial blood gas analyses in the five groups

Group	pH	PaO₂ (mmHg)	PaCO₂ (mmHg)
Sham	7.28 ± 0.02	117.50 ± 5.68	38.00 ± 2.61
Dex	7.29 ± 0.02	117.83 ± 2.14	38.67 ± 2.16
IR	7.03 ± 0.05**	93.67 ± 5.01**	29.83 ± 1.17**
Dex + IR	7.09 ± 0.01**^,#	98.83 ± 1.47**	31.33 ± 1.03**
Atip + Dex + IR	7.00 ± 0.07**	92.17 ± 6.18**	29.00 ± 1.41**

C57B/6J mice were pre-treated with dexmedetomidine (Dex) alone or in combination with α₂-adrenoceptor antagonist atipamezole (Atip) followed by clamping of the bilateral renal pedicle for 60 min and reperfusion for 24 h. Sham animals were used as control. Data are shown as mean ± SD. n = 6 per group, ** p < 0.01 versus sham group, ^# p < 0.01 versus IR group

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