Fig. 5
From: Recombinant mouse periostin ameliorates coronal sutures fusion in Twist1+/− mice
Periostin ameliorates coronal synostosis in Twist1+/− mice in vivo. a Micro-CT shows that recombinant mouse periostin can suppress the coronal suture synostosis of Twist1+/− mice (arrows, coronal suture). b Coronal sutures bone volume fraction analysis. After treatment with recombinant mouse periostin, the bone volume fraction of coronal suture decreased significantly (p < 0.01). c Hematoxylin and eosin staining to observe the osteogenic fronts of coronal sutures; the osteogenic fronts of the Twist1+/− mice remain detached after treatment for 3 weeks (arrows, osteogenic fronts). Original magnifications: ×50. Bar: 50 μm. *p < 0.05, **p < 0.01