Fig. 3

Functional significance of toxicity-associated antibodies. a Functional pathway enrichment (WikiPathways) of protein targets from the filtered set of toxicity-associated antibodies from anti-CTLA-4-treated patients. b As for a, but for anti-PD-1-treated patients. c As for a, but for combination-treated patients. d Summary of immune toxicity associations for protein targets of top 15 DE termination-associated antibodies from anti-CTLA-4-treated patients. e As for d, but for anti-PD-1-treated patients. f As for d, but for combination-treated patients