|
Intestinal type
|
Pancreatobiliary type
|
All
|
---|
n (events)
|
Unadjusted
|
Adjusted
|
n (events)
|
Unadjusted
|
Adjusted
|
n (events)
|
Unadjusted
|
Adjusted
|
---|
HR (95% CI)
|
HR (95% CI)
|
HR (95% CI)
|
HR (95% CI)
|
HR (95% CI)
|
HR (95% CI)
|
---|
Age
|
Continuous
|
63 (39)
|
1.01 (0.98–1.05)
|
–
|
109 (98)
|
0.99 (0.97–1.02)
|
–
|
172 (137)
|
1.01 (0.99–1.03)
|
–
|
Gender
|
Female
|
35 (17)
|
1.00
|
1.00
|
51 (45)
|
1.00
|
–
|
86 (62)
|
1.00
|
–
|
34 (16)*
|
Male
|
28 (22)
|
2.01 (1.05–3.84)
|
1.60 (0.79–3.24)
|
58 (53)
|
1.15 (0.77–1.71)
| |
86 (75)
|
1.40 (1.00–1.97)
| |
|
27 (21)*
| | | | | | | | |
Tumor origin
|
Intestinal
| |
–
|
–
| |
–
|
–
|
63 (39)
|
1.00
|
1.00
|
| | | | | | |
61 (37)*
| | |
Pancreatobiliary type
| |
–
|
–
| |
–
|
–
|
109 (98)
|
2.54 (1.73–3.73)
|
1.61 (1.01–2.55)
|
| | | | | | |
108 (98)*
| | |
Tumor size
|
Continuous
|
63 (39)
|
1.00 (0.98–1.02)
|
–
|
109 (98)
|
1.04 (1.02–1.06)
|
1.02 (1.00–1.04)
|
172 (137)
|
1.02 (1.00–1.03)
|
1.01 (0.99–2.55)
|
| | | |
108 (98)*
| | |
169 (135)*
| | |
T-stage
|
T1–T2
|
16 (8)
|
1.00
|
–
|
15 (10)
|
1.00
|
1.00
|
31 (18)
|
1.00
|
1.00
|
| | | |
14 (10)*
| | |
28 (16)*
| | |
T3–T4
|
47 (31)
|
1.72 (0.79–3.74)
| |
94 (88)
|
2.47 (1.28–4.77)
|
1.06 (0.50–2.27)
|
141 (119)
|
2.34 (1.42–3.86)
|
1.21 (0.66–2.21)
|
| | | |
94 (88)*
| | |
141 (119)*
| | |
N-stage
|
N0
|
35 (19)
|
1.00
|
–
|
32 (25)
|
1.00
|
1.00
|
67 (44)
|
1.00
|
1.00
|
| | | |
31 (25)*
| | |
64 (42)*
| | |
N1–2
|
28 (20)
|
1.56 (0.83–2.94)
| |
77 (73)
|
2.23 (1.41–3.54)
|
2.06 (1.16–3.65)
|
105 (93)
|
2.19 (1.52–3.16)
|
1.34 (0.88–2.05)
|
| | | |
77 (73)*
| | |
105 (93)*
| | |
Differentiation grade
|
Well-moderate
|
31 (17)
|
1.00
|
–
|
42 (32)
|
1.00
|
1.00
|
73 (49)
|
1.00
|
1.00
|
| | | |
41 (32)*
| | |
71 (48)*
| | |
Poor
|
32 (22)
|
1.70 (0.90–3.21)
| |
67 (66)
|
2.63 (1.70–4.09)
|
2.05 (1.24–3.39)
|
99 (88)
|
2.24 (1.57–3.18)
|
1.65 (1.09–2.48)
|
| | | |
67 (66)*
| | |
98 (87)*
| | |
Involved margins, status
|
R0
|
18 (5)
|
1.00
|
1.00
|
7 (5)
|
1.00
|
–
|
25 (10)
|
1.00
|
1.00
|
|
17 (4)*
| | | | | |
23 (9)*
| | |
R1 and Rx
|
45 (34)
|
3.30 (1.29–8.46)
|
2.89 (0.94–8.85)
|
102 (93)
|
2.42 (0.98–6.00)
| |
147 (127)
|
3.57 (1.87–6.83)
|
2.23 (1.10–4.51)
|
|
44 (33)*
| | | | | |
146 (126)*
| | |
Lymphatic growth
|
Absent
|
28 (10)
|
1.00
|
1.00
|
35 (27)
|
1.00
|
1.00
|
63 (37)
|
1.00
|
1.00
|
|
28 (10)*
| | |
34 (27)*
| | |
62 (37)*
| | |
Present
|
35 (29)
|
3.94 (1.90–8.18)
|
1.77 (0.77–4.09)
|
74 (71)
|
1.78 (1.13–2.79)
|
1.09 (0.65–1.83)
|
109 (100)
|
2.54 (1.73–3.73)
|
1.33 (0.85–2.07)
|
|
33 (27)*
| | |
74 (71)*
| | |
107 (98)*
| | |
Vascular growth
|
Absent
|
58 (34)
|
1.00
|
1.00
|
73 (62)
|
1.00
|
1.00
|
131 (96)
|
1.00
|
1.00
|
|
56 (32)*
| | |
72 (62)*
| | |
128 (94)*
| | |
Present
|
5 (5)
|
6.68 (2.40–18.62)
|
4.69 (1.48–14.84)
|
36 (36)
|
2.47 (1.61–3.80)
|
2.20 (1.38–3.52)
|
41 (41)
|
3.49 (2.37–5.15)
|
2.18 (1.43–3.34)
|
|
5 (5)*
| | |
36 (36)*
| | |
41 (41)*
| | |
Perineural growth
|
Absent
|
43 (21)
|
1.00
|
1.00
|
25 (19)
|
1.00
|
1.00
|
68 (40)
|
1.00
|
1.00
|
|
42 (20)*
| | |
24 (19)*
| | |
66 (39)*
| | |
Present
|
20 (18)
|
2.81 (1.48–5.35)
|
1.36 (0.57–3.21)
|
84 (79)
|
1.96 (1.18–3.25)
|
0.88 (0.48–1.61)
|
104 (97)
|
2.96 (2.02–4.43)
|
1.06 (0.66–1.71)
|
|
19 (17)*
| | |
84 (79)*
| | |
103 (96)*
| | |
Growth in peripancreatic fat
|
Absent
|
42 (20)
|
1.00
|
1.00
|
25 (20)
|
1.00
|
1.00
|
67 (40)
|
1.00
|
1.00
|
|
40 (18)*
| | |
24 (20)*
| | |
64 (38)*
| | |
Present
|
21 (19)
|
3.65 (1.86–7.16)
|
1.78 (0.73–4.33)
|
84 (78)
|
1.75 (1.06–2.88)
|
0.99 (0.56–1.77)
|
105 (97)
|
3.00 (2.03–4.43)
|
1.37 (0.85–2.22)
|
|
21 (19)*
| | |
84 (78)*
| | |
105 (97)*
| | |
Adjuvant treatment
|
None
|
45 (30)
|
1.00
|
–
|
50 (44)
|
1.00
|
–
|
95 (74)
|
1.00
|
–
|
Any
|
18 (9)
|
0.69 (0.33–1.47)
| |
59 (54)
|
0.96 (0.64–1.42)
| |
77 (63)
|
1.09 (0.78–1–53)
| |
MMR
|
pMMR
|
49 (34)
|
1.00
|
1.00
|
101 (93)
|
1.00
|
1.00
|
150 (127)
|
1.00
|
1.00
|
|
49 (34)*
| | |
101 (93)*
| | |
150 (127)*
| | |
dMMR
|
12 (3)
|
0.20 (0.06–0.68)
|
0.36 (0.09–1.42)
|
7 (5)
|
0.57 (0.23–1.42)
|
1.24 (0.46–3.37)
|
19 (8)
|
0.28 (0.13–0.57)
|
0.52 (0.23–1.19)
|
|
12 (3)*
| | |
7 (5)*
| | |
19 (8)*
| | |
- Italic values indicate significance at p < 0.05
- *Number and events for the adjusted analysis