Fig. 7
TEMRA and TCM cells responses to CVD 1208S, 28 days after first immunization. a, c, e, g The comparison of single function (S+) versus multifunctional (MF) CD8 TEMRA, CD4 TEMRA, CD8 TCM, and CD4 TCM cells respectively, in response to CVD1208S immunization. b, d, f, h display the comparison of cells that showed more than one simultaneous function (e.g., increased cytokine production or CD107a upregulation) in CD8 TEMRA, CD4 TEMRA, CD8 TCM, and CD4 TCM cells, respectively. Means are indicated in each graph. *P < 0.05 (Mann–Whitney). i The relative frequency (expressed as percentage) of the 5 most prevalent MF populations in CD8 TEMRA, CD4 TEMRA, CD8 TCM, and CD4 TCM cells. The remaining MF populations were pooled in a single group indicated as other