Fig. 6

Upregulation of CD107a and cytokine production by T_EMRA and T_CM cells after CVD 1208S immunizations. a CD107a upregulation [% net change (day 28 minus day0)] or cytokine production by CD8_EMRA (left panel) and CD4T_EMRA (right panel) cells in CVD 1208S recipients 28 days after the first immunization. b Similar data are presented for CD8 and CD4 T_CM cells. c, d A summary of CD107a upregulation or cytokine production 28 days after each immunization (days 28, 56 and 84) in each vaccinated individual. The data shown corresponds to CD8 and CD4 T_EMRA, as well as CD8 and CD4 T_CM cells. Volunteers who upregulated CD107a or produced cytokines are indicated with a + sign in a green box (data are derived from % net changes relative to day 0). In the blue boxes the number (and percentage) of vaccinated volunteers that produced at least one cytokine or upregulated CD107a after each immunization are indicated. The gray boxes indicate the number (and percentage) of vaccinated volunteers that exhibited increases in at least one cytokine or upregulated CD107a after receiving the three vaccine doses