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Table 1 Insulin therapy and feed algorithms for the maintenance of blood glucose and weight gain

From: Alloxan-induced diabetes exacerbates coronary atherosclerosis and calcification in Ossabaw miniature swine with metabolic syndrome

Measurements

Adjustments

Blood glucose (mg/dL)

Behavior

Body weight (kg)

Insulin glargine (U)

Food (by weight)

> Diabetic target range of 120–200

Normal

 

Base + 0.1 U/kg

No Change

> Diabetic target range of 120–180

Lethargic

 

Base + 0.2 U/kg

No Change

120–200

Normal

 

Base (0.1–0.3 U/kg)

No Change

< Diabetic target range of 120–200

Normal

 

Base (0.1–0.3 U/kg)

Increase 15%

< Diabetic target range of 120–200

Lethargic

 

Base (0.1–0.3 U/kg)

Increase 15%

  

Decrease > 5%

in one week

Base + 1 U/kg

Increase 30%

  

Less than target

weight gain at

weeks 4, 8, 12, 16, 20

No change

Increase 15%

  

Increase > 10% in 1 week

No change

Decrease 15%

  

> 10% over

target weight gain at weeks 4, 8, 12, 16, 20

No change

Decrease 15%