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Table 1 Insulin therapy and feed algorithms for the maintenance of blood glucose and weight gain

From: Alloxan-induced diabetes exacerbates coronary atherosclerosis and calcification in Ossabaw miniature swine with metabolic syndrome

Measurements Adjustments
Blood glucose (mg/dL) Behavior Body weight (kg) Insulin glargine (U) Food (by weight)
> Diabetic target range of 120–200 Normal   Base + 0.1 U/kg No Change
> Diabetic target range of 120–180 Lethargic   Base + 0.2 U/kg No Change
120–200 Normal   Base (0.1–0.3 U/kg) No Change
< Diabetic target range of 120–200 Normal   Base (0.1–0.3 U/kg) Increase 15%
< Diabetic target range of 120–200 Lethargic   Base (0.1–0.3 U/kg) Increase 15%
   Decrease > 5%
in one week
Base + 1 U/kg Increase 30%
   Less than target
weight gain at
weeks 4, 8, 12, 16, 20
No change Increase 15%
   Increase > 10% in 1 week No change Decrease 15%
   > 10% over
target weight gain at weeks 4, 8, 12, 16, 20
No change Decrease 15%