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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Alloxan-induced diabetes exacerbates coronary atherosclerosis and calcification in Ossabaw miniature swine with metabolic syndrome

Fig. 5

MetS/D-A swine had more advanced disease than lean and MetS-A swine. a Angiogram showing the LAD and CFX coronary arteries. All IVUS still frames collected for analysis were from the proximal 45 mm of the LAD. b Representative IVUS image of the LAD of a MetS/D-A swine showing 100% wall coverage, the percent of the circumference of the arterial wall covered by intimal thickening (original lumen highlighted in red, intimal thickening highlighted in yellow). c Representative IVUS image of the LAD of a MetS/D-A swine illustrating plaque burden, the percent of original lumen that is now occupied by a lesion (original lumen highlighted in red, new lumen with lesion highlighted in yellow). d The MetS/D-A swine had significantly greater wall coverage compared to MetS-A and lean swine. e The MetS/D-A swine had significantly greater plaque burden, compared to MetS-A and lean swine. *p < 0.05 compared with lean swine; p < 0.05 compared with MetS-A swine. (Lean = 6; MetS-A = 7; MetS/D-A = 7.)

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