Fig. 4
IHC shows diminished pancreatic beta cell mass in MetS-A and MetS/D-A swine. Immunohistochemical analysis using antibodies against insulin revealed that beta cell mass was decreased in MetS-A swine as compared to lean swine, and even less in MetS/D-A swine. Taken together, these data show that swine in the MetS/D-A group were indeed diabetic, due to alloxan-induced beta-cell damage. *p < 0.05 compared with lean swine; ‡p < 0.05 compared with MetS-A swine. (Lean = 7; MetS-A = 7; MetS/D-A = 8.)