Fig. 2
From: Physiological and molecular effects of interleukin-18 administration on the mouse kidney
No side effects were observed with rIL-18 administration for 2 weeks. To analyze the effects on renal function, mice were injected with rIL-18 twice a week for 2 weeks from 10 weeks of age (short-term treatment). Serum levels of BUN (a) and CREA (b) are shown. Data are mean ± SD (a, b: n = 8 per group). c Hematoxylin–eosin, d periodic acid–Schiff, and e periodic acid methenamine silver staining. Scale bars represent 50 μm (c–e). BUN: blood urea nitrogen; CREA: creatinine