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Table 5 Comparison of sensitivity and specificity of previously published panels with values obtained for this new panel

From: A novel DNA methylation panel accurately detects colorectal cancer independently of molecular pathway

Panels Sensitivity (%) Specificity (%) AUC Accuracy Specimen type Methods References
NGFR; SEPT9; TMEFF2 NA NA 0.890 NA Tissue qMSP [39]
NGFR; SEPT9; TMEFF2; bisDNA 0.790 NA Plasma
APC; MGMT; RASSF2A; Wif-1 86.5 92.1 0.927 89.2 Plasma MSP [14]
SFRP2; RASSF2a 75.0 89.4 NA NA Stool COBRA, Hi-SA [40]
BMP3; NDRG4; TFPI2; Vimentin 78.0 85.0 0.880 91.2 Stool QuARTS [41]
HLTF; HPP1; MLH1 NA NA NA NA Plasma qMSP [42]
DCC; UNC5C 82.0 NA NA NA Tissue qMSP [43]
HPP1; MGMT; SFRP2 93.7 77.1 NA NA Stool MSP [36]
IGFBP3; miR137 95.5 90.5 NA 86.0 Tissue Bisulfite pyrosequencing [44]
CNRIP1; FBN1; INA; MAL; SNCA; SPG20b 94.0 98.0 0.984 95.5 Tissue qMSP [45]
CMTM3; MDFI; SSTR2 81.0 91.0 0.920 NA Tissue Bisulfite pyrosequencing [46]
MGMT; RASSF1A; SEPT9 96.6 74.0 0.970 90.8 Tissue qMSP
  1. COBRA combined bisulfite restriction analysis, Hi-SA high-sensitivity assay for bisulfite DNA, NA not available for the panel of genes, QuARTS quantitative allele-specific real-time target and signal amplification
  2. a Also detects gastric cancer
  3. b Co-methylation of two out of six genes
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