Table 5 Comparison of sensitivity and specificity of previously published panels with values obtained for this new panel
Panels | Sensitivity (%) | Specificity (%) | AUC | Accuracy | Specimen type | Methods | References |
|---|---|---|---|---|---|---|---|
NGFR; SEPT9; TMEFF2 | NA | NA | 0.890 | NA | Tissue | qMSP | [39] |
NGFR; SEPT9; TMEFF2; bisDNA | 0.790 | NA | Plasma | ||||
APC; MGMT; RASSF2A; Wif-1 | 86.5 | 92.1 | 0.927 | 89.2 | Plasma | MSP | [14] |
SFRP2; RASSF2a | 75.0 | 89.4 | NA | NA | Stool | COBRA, Hi-SA | [40] |
BMP3; NDRG4; TFPI2; Vimentin | 78.0 | 85.0 | 0.880 | 91.2 | Stool | QuARTS | [41] |
HLTF; HPP1; MLH1 | NA | NA | NA | NA | Plasma | qMSP | [42] |
DCC; UNC5C | 82.0 | NA | NA | NA | Tissue | qMSP | [43] |
HPP1; MGMT; SFRP2 | 93.7 | 77.1 | NA | NA | Stool | MSP | [36] |
IGFBP3; miR137 | 95.5 | 90.5 | NA | 86.0 | Tissue | Bisulfite pyrosequencing | [44] |
CNRIP1; FBN1; INA; MAL; SNCA; SPG20b | 94.0 | 98.0 | 0.984 | 95.5 | Tissue | qMSP | [45] |
CMTM3; MDFI; SSTR2 | 81.0 | 91.0 | 0.920 | NA | Tissue | Bisulfite pyrosequencing | [46] |
MGMT; RASSF1A; SEPT9 | 96.6 | 74.0 | 0.970 | 90.8 | Tissue | qMSP | – |