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Table 2 Performance of epigenetic biomarkers for CRC’s detection in tissue samples

From: A novel DNA methylation panel accurately detects colorectal cancer independently of molecular pathway

Gene/panels

Sensitivity (n/N)

Specificity (n/N)

AUC

PPV

NPV

Accuracy

SEPT9

85.5 (124/145)

94.0 (3/50)

0.950

97.6

69.1

87.7

MGMT/SEPT9

93.8 (136/145)

82.0 (9/50)

0.964

93.8

82.0

90.8

MGMT/RASSF1A/SEPT9

96.6 (140/145)

74.0 (13/50)

0.970

91.5

88.1

90.8

  1. Sensitivity, Specificity, PPV and NPV values are represented in percentage
  2. AUC Area under the curve, NPV negative predictive value, PPV positive predictive value
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Journal of Translational Medicine

ISSN: 1479-5876

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