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Table 2 Performance of epigenetic biomarkers for CRC’s detection in tissue samples

From: A novel DNA methylation panel accurately detects colorectal cancer independently of molecular pathway

Gene/panels Sensitivity (n/N) Specificity (n/N) AUC PPV NPV Accuracy
SEPT9 85.5 (124/145) 94.0 (3/50) 0.950 97.6 69.1 87.7
MGMT/SEPT9 93.8 (136/145) 82.0 (9/50) 0.964 93.8 82.0 90.8
MGMT/RASSF1A/SEPT9 96.6 (140/145) 74.0 (13/50) 0.970 91.5 88.1 90.8
  1. Sensitivity, Specificity, PPV and NPV values are represented in percentage
  2. AUC Area under the curve, NPV negative predictive value, PPV positive predictive value
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