Clinical significance of circulating microRNAs as markers in detecting and predicting congenital heart defects in children

Table 2 ROC curve analysis showing the discriminative power of the selected microRNAs (miRNA) or the combined form in children and maternal populations

Population	Phenotype	miRNA	AUC	95% CI	p value
Children	CHD	hsa-let-7a	0.544	0.368–0.720	0.601
		hsa-let-7b	0.656	0.486–0.816	0.063
		hsa-miR-486	0.755	0.622–0.888	0.002
		All three combined	0.783	0.653–0.912	0.001
Children	ASD	hsa-let-7a	0.833	0.641–1.000	0.002
		hsa-let-7b	0.900	0.764–1.000	< 0.001
		hsa-miR-486	0.806	0.516–0.895	0.068
		All three combined	0.877	0.700–1.000	0.001
Mother	ASD	hsa-let-7a	0.917	0.822–1.000	< 0.001
		hsa-let-7b	0.680	0.482–0.877	0.097
		hsa-miR-486	0.562	0.297–0.827	0.567
		hsa-let-7a/hsa-let-7b	0.909	0.810–1.000	0.050

ROC receiver-operating characteristic, AUC area under an ROC curve, CHD congenital heart defects, including the three types of septal defects, ASD atrial septal defects, CI confidence interval

ISSN: 1479-5876