Fig. 1

The combination drug ameliorated DSS-induced colitis. C57BL/6 mice were treated orally with 3% DSS in distilled water ad libitum from days 0 to 4 and thereafter received regular drinking water. On day 3 after DSS administration, the probiotic complex or the combination drug (100 mg/mouse) was administered orally (n = 5/group). a Changes in body weight expressed as percentages of body weight on day 0. b With the exception of day 7, the DAI was monitored daily. Data are means ± SDs of four independent experiments. c Colon length of mice with DSS-induced chronic colitis on day 10. Macroscopic images of the colon (left panel). Colon length (right panel). d Representative hematoxylin and eosin-stained images of the colon on day 10. Scale bar, 100 µm. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001. Vehicle vs. probiotic complex or combination drug treatment