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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients

Fig. 3

Relationships between genes from COPD specific modules (disease effects) and previous experimental data. a The relationships between S100A1, from the Ca2+ dependent binding module, and VO2max. The two groups, healthy subjects (blue circles) and COPD patients (low and normal FFMI, empty and filled squares, respectively) fell on the same regression line (R = 0.52, P = 0.006, FDR = 0.026). b The relationships between SMURF1 from the TGF-β signaling module and skeletal muscle nitrosative stress. A statistical significant correlation was seen in the COPD group, both normal and low FFMI (R = − 0.67, P = 0.018 and FDR = 0.07), but not in healthy subjects (R = − 0.2, P = 0.55)

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