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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Turning the tables on cytomegalovirus: targeting viral Fc receptors by CARs containing mutated CH2–CH3 IgG spacer domains

Fig. 1

gB-specific CAR T cells secrete IFN-γ and TNF in response to HCMV-infected cells. a Flow cytometric analysis of CAR expression in anti-CD3/CD28-activated T cells 1 day after mRNA electroporation. CARs were detected via an anti-human-IgG antibody. b Flow cytometric analysis of HCMV-gB expression in uninfected HFF and in HFF 4 days after infection (AD169; MOI 5). c and d Absolute amounts of IFN-γ (c) and TNF (d) secreted by anti-CD3/CD28-expanded T cells 1 day after electroporation of CAR-mRNA. T cells were co-cultured for 4 h with uninfected and infected HFF (day 4 p.i., AD169, MOI 5)

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Journal of Translational Medicine

ISSN: 1479-5876

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