|
Variables
|
Overall survival (OS)
|
Progression-free survival (PFS)
|
Locoregional recurrence-free survival (LRFFS)
|
Distant metastasis-free survival (DMFS)
|
|---|
|
HR (95% CI)a
|
P value
|
HR (95% CI)a
|
P value
|
HR (95% CI)a
|
P value
|
HR (95% CI)a
|
P value
|
|---|
|
Age
|
|
≤ 60
| | | | | | |
Ref
| |
|
> 60
| | | | | | |
2.510 (1.376–4.580)
|
0.003
|
|
Primary tumor site
|
|
Pyriform sinus
|
Ref
| |
Ref
| |
Ref
| |
Ref
| |
|
Posterior wall/postcricoid
|
2.590 (1.252–5.358)
|
0.010
|
2.328 (1.224–4.426)
|
0.010
|
2.608 (1.163–5.851)
|
0.020
|
2.914 (1.296–6.553)
|
0.010
|
|
pT classificationb
|
|
T1–T2
| | |
Ref
| |
Ref
| | | |
|
T3–T4
| | |
1.842 (1.115–3.042)
|
0.005
|
3.063 (1.559–6.015)
|
0.001
| | |
|
pN classificationb
|
|
N0
| | | | | | |
Ref
| |
|
N1–N3
| | | | | | |
2.519 (0.335–18.963)
|
0.370
|
|
pTNM stagingb
|
|
I–II
| | | | | | |
Ref
| |
|
III–IV
| | | | | | |
1.126 (0.151–8.402)
|
0.908
|
|
No. of metastatic LN
|
|
≤ 3
| | | | | | |
Ref
| |
|
> 3
| | | | | | |
1.497 (0.731–3.066)
|
0.269
|
|
LND
|
|
≤ 0.06
|
Ref
| |
Ref
| | | |
Ref
| |
|
> 0.06
|
1.959 (0.959–2.974)
|
0.070
|
1.971 (1.201–3.237)
|
0.007
| | |
2.430 (1.206–4.896)
|
0.013
|
|
ECS of LN
|
|
Negative
|
Ref
| | | | | |
Ref
| |
|
Positive
|
1.670 (0.866–3.222)
|
0.126
| | | | |
1.326 (0.665–2.647)
|
0.423
|
|
Surgical margin
|
|
Negative
|
Ref
| |
Ref
| |
Ref
| | | |
|
Positive
|
2.842 (1.080–7.482)
|
0.034
|
1.790 (0.767–4.179)
|
0.178
|
3.455 (1.253–9.526)
|
0.017
| | |
|
PNI
|
|
> 52.0
|
Ref
| |
Ref
| |
Ref
| |
Ref
| |
|
≤ 52.0
|
3.842 (1.963–7.518)
|
0.000
|
2.401 (1.419–4.061)
|
0.001
|
2.958 (1.388–6.307)
|
0.005
|
2.133 (1.154–3.943)
|
0.016
|
- Italic values indicate significance of p value (p < 0.05)
- CI, confidence interval; ECS, extracapsular spread; HR, hazard ratio; LN, lymph node; LND, lymph node density; PNI, prognostic nutritional index; pT classification, pathological tumor classification; pN classification, pathological nodal classification; Ref, reference; TNM, tumor-node-metastasis
- aCox proportional hazards model. Bolding shows P value < 0.05
- bTumor-node-metastasis staging system proposed by the American Joint Committee on Cancer (7th edition)
