Fig. 3
From: Gamma-delta (γδ) T cells: friend or foe in cancer development?
The functions of γδ T cells are influenced by the TME. The balance of pro- and anti-inflammatory cytokines and the cellular state govern the function of γδ T cells. Tumor and stromal cells produce a variety of cytokines and chemokines that either contribute to or disrupt the development of a pro-tumorigenic niche. These factors can also reprogram γδ T cells to adopt a protumor or antitumor state