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Table 4 Performance characteristics of Tetraplex system with reference to QMVR for identification of MMR-deficient ECs in the validation set (n = 138)

From: Accuracy of four mononucleotide-repeat markers for the identification of DNA mismatch-repair deficiency in solid tumors

No. of markers displaying allelic variation The Tetraplex marker panel
Sensitivity (%)  Specificity (%) PPV (%) NPV (%)
4 70.7 (55.5–82.4) 100 (96.2–100) 100 (88.3–100) 89.0 (81.7–93.6)
3 85.4 (71.6–93.1) 100 (96.2–100) 100 (90.1–100) 94.2 (87.9–97.3)
2 87.8 (74.5–94.7) 100 (96.2–100) 100 (90.4–100) 95.1 (89.0–97.9)
1 92.7 (80.6–97.5) 97.9 (92.8–99.4) 95.0 (83.5–98.6) 96.9 (91.4–99.0)
  1. Results are expressed as percentages (%), with 95% confidence intervals in parentheses
  2. PPV positive predictive value, NPV negative predictive value