Table 4 Performance characteristics of Tetraplex system with reference to QMVR for identification of MMR-deficient ECs in the validation set (n = 138)
No. of markers displaying allelic variation | The Tetraplex marker panel | |||
|---|---|---|---|---|
Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | |
4 | 70.7 (55.5–82.4) | 100 (96.2–100) | 100 (88.3–100) | 89.0 (81.7–93.6) |
3 | 85.4 (71.6–93.1) | 100 (96.2–100) | 100 (90.1–100) | 94.2 (87.9–97.3) |
2 | 87.8 (74.5–94.7) | 100 (96.2–100) | 100 (90.4–100) | 95.1 (89.0–97.9) |
1 | 92.7 (80.6–97.5) | 97.9 (92.8–99.4) | 95.0 (83.5–98.6) | 96.9 (91.4–99.0) |