Skip to main content

Advertisement

Table 3 Performance characteristics of each MSI marker for the identification of MMR-deficient ECs in validation test set (n = 138)

From: Accuracy of four mononucleotide-repeat markers for the identification of DNA mismatch-repair deficiency in solid tumors

Marker References Sensitivity% (95% CI) Specificity% (95% CI) for pMMR PPV% (95%CI) for dMMR NPV% (95% CI) for pMMR
CAT25 QMVR (106–108 bp) for dMMR (n = 41) 80.5 (66.0–89.8) 100 (96.2–100) 100 (89.6–100) 92.4 (85.7–96.1)
dMLH1 (n = 23) 82.6 (62.9–93.0)
dMSH2 (n = 8) 100 (67.5–100)
dMSH6 (n = 8) 50.0 (21.5–78.5)
dPMS2 (n = 2) 100 (34.2–100)
NR21 QMVR (131–134 bp) for dMMR (n = 41) 78.1 (63.3–88.0) 99.0 (94.4–99.8) 97.0 (84.7–99.5) 91.4 (84.5–95.4)
dMLH1 (n = 23) 69.6 (49.1–84.4)
dMSH2 (n = 8) 100 (67.5–100)
dMSH6 (n = 8) 62.5 (30.6–86.3)
dPMS2 (n = 2) 100 (34.2–100)
NR27 QMVR (153–156 bp) for dMMR (n = 41) 90.2 (77.5–96.1) 99.0 (94.4–99.8) 97.4 (86.5–99.5) 96.0 (90.2–98.4)
dMLH1 (n = 23) 95.7 (79.0–99.2)
dMSH2 (n = 8) 100 (67.5–100)
dMSH6 (n = 8) 62.5 (30.6–86.3)
dPMS2 (n = 2) 100 (34.2–100)
BAT26 QMVR (175–177 bp) for dMMR (n = 39) 87.8 (74.5–94.7) 100 (96.2–100) 100 (90.4–100) 95.1 (89.0–97.9)
dMLH1 (n = 23) 91.3 (73.2–97.6)
dMSH2 (n = 8) 100 (67.5–100)
dMSH6 (n = 8) 62.5 (30.6–86.3)
dPMS2 (n = 2) 100 (34.2–100)
  1. PPV, positive predictive value, NPV negative predictive value