Table 2 Changes in relative placental mRNA and miRNA expression associated with ponderal index and birth weight, for a doubling in gene expression
Gene | Ponderal index | Birth weight | ||
|---|---|---|---|---|
% change (95% CI) | p-value | % change (95% CI) | p-value | |
Girls and boys (n = 206) | ||||
HIF1α | − 6.68 (− 12.01, − 1.34) | 0.01 | − 10.79 (− 83.67, 62.09) | 0.77 |
COX-10 | 0.26 (− 9.96, 10.49) | 0.96 | 45.70 (− 94.56, 185.97) | 0.52 |
ISCU | − 1.20 (− 8.18, 5.78) | 0.73 | 7.58 (− 86.83, 101.99) | 0.87 |
RAD52 | − 6.16 (− 12.10, − 0.22) | 0.04 | − 47.73 (− 127.70, 32.24) | 0.24 |
PTEN | − 4.57 (− 10.27, 1.13) | 0.12 | − 11.20 (− 88.94, 32.24) | 0.78 |
miR-210 | − 1.18 (− 3.36, 0.99) | 0.28 | − 5.42 (− 34.84, 24.00) | 0.72 |
miR-20a | − 2.08 (− 4.37, 0.22) | 0.08 | 3.52 (− 27.55, 34.59) | 0.82 |
Boys (n = 96) | ||||
HIF1α | − 7.67 (− 16.18, 0.83) | 0.08 | − 96.16 (− 210.5, 18.17) | 0.10 |
COX-10 | 3.03 (− 19.66, 13.59) | 0.72 | − 16.74 (− 250.22, 216.74) | 0.89 |
ISCU | 7.81 (− 18.33, 3.21) | 0.16 | − 30.88 (− 188.06, 126.31) | 0.70 |
RAD52 | − 5.14 (− 13.98, 3.70) | 0.25 | 76.71 (− 201.02, 47.59) | 0.22 |
PTEN | − 1.77 (− 12.33, 8.80) | 0.74 | 3.01 (− 146.07, 152.09) | 0.97 |
miR-210 | − 0.93 (− 4.38, 2.51) | 0.59 | − 4.56 (− 51.57, 42.45) | 0.85 |
miR-20a | − 0.25 (− 4.43, 3.93) | 0.91 | 54.19 (0.57, 107.82) | 0.05 |
Girls (n = 110) | ||||
HIF1α | − 7.56 (− 14.97, − 0.14) | 0.05 | 7.15 (− 88.27, 102.58) | 0.88 |
COX-10 | 5.54 (− 8.46, 19.55) | 0.43 | 160.21 (− 20.17, 340.59) | 0.08 |
ISCU | 2.73 (− 6.81, 12.27) | 0.57 | 33.04 (− 87.12, 153.19) | 0.59 |
RAD52 | − 5.19 (− 13.91, 3.53) | 0.24 | − 72.35 (− 181.64, 36.94) | 0.19 |
PTEN | 5.22 (− 12.56, 2.11) | 0.16 | − 15.45 (− 110.14, 79.25) | 0.75 |
miR-210 | − 0.86 (− 3.90, 2.18) | 0.58 | 11.27 (− 28.00, 50.54) | 0.57 |
miR-20a | − 2.06 (− 5.02, 0.91) | 0.17 | − 15.46 (− 53.97, 23.04) | 0.43 |