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Table 2 Changes in relative placental mRNA and miRNA expression associated with ponderal index and birth weight, for a doubling in gene expression

From: Placental hypoxia-regulating network in relation to birth weight and ponderal index: the ENVIRONAGE Birth Cohort Study

Gene Ponderal index Birth weight
% change (95% CI) p-value % change (95% CI) p-value
Girls and boys (n = 206)
 HIF1α − 6.68 (− 12.01, − 1.34) 0.01 − 10.79 (− 83.67, 62.09) 0.77
 COX-10 0.26 (− 9.96, 10.49) 0.96 45.70 (− 94.56, 185.97) 0.52
 ISCU − 1.20 (− 8.18, 5.78) 0.73 7.58 (− 86.83, 101.99) 0.87
 RAD52 − 6.16 (− 12.10, − 0.22) 0.04 − 47.73 (− 127.70, 32.24) 0.24
 PTEN − 4.57 (− 10.27, 1.13) 0.12 − 11.20 (− 88.94, 32.24) 0.78
 miR-210 − 1.18 (− 3.36, 0.99) 0.28 − 5.42 (− 34.84, 24.00) 0.72
 miR-20a − 2.08 (− 4.37, 0.22) 0.08 3.52 (− 27.55, 34.59) 0.82
Boys (n = 96)
 HIF1α − 7.67 (− 16.18, 0.83) 0.08 − 96.16 (− 210.5, 18.17) 0.10
 COX-10 3.03 (− 19.66, 13.59) 0.72 − 16.74 (− 250.22, 216.74) 0.89
 ISCU 7.81 (− 18.33, 3.21) 0.16 − 30.88 (− 188.06, 126.31) 0.70
 RAD52 − 5.14 (− 13.98, 3.70) 0.25 76.71 (− 201.02, 47.59) 0.22
 PTEN − 1.77 (− 12.33, 8.80) 0.74 3.01 (− 146.07, 152.09) 0.97
 miR-210 − 0.93 (− 4.38, 2.51) 0.59 − 4.56 (− 51.57, 42.45) 0.85
 miR-20a − 0.25 (− 4.43, 3.93) 0.91 54.19 (0.57, 107.82) 0.05
Girls (n = 110)
 HIF1α − 7.56 (− 14.97, − 0.14) 0.05 7.15 (− 88.27, 102.58) 0.88
 COX-10 5.54 (− 8.46, 19.55) 0.43 160.21 (− 20.17, 340.59) 0.08
 ISCU 2.73 (− 6.81, 12.27) 0.57 33.04 (− 87.12, 153.19) 0.59
 RAD52 − 5.19 (− 13.91, 3.53) 0.24 − 72.35 (− 181.64, 36.94) 0.19
 PTEN 5.22 (− 12.56, 2.11) 0.16 − 15.45 (− 110.14, 79.25) 0.75
 miR-210 − 0.86 (− 3.90, 2.18) 0.58 11.27 (− 28.00, 50.54) 0.57
 miR-20a − 2.06 (− 5.02, 0.91) 0.17 − 15.46 (− 53.97, 23.04) 0.43