Comprehensive molecular biomarker identification in breast cancer brain metastases

Table 2 Top pathways and networks based on the differentially expressed probe sets

Category	BCBM vs. BC intersecting with BCBM vs. prBT			BCBM shared with prBT
Category	p-value	Overlap (%)	Score	p-value	Overlap (%)	Score
Top canonical pathways
Role of BRCA1 in DNA damage response	1.04E−03	7.7
d-Myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis	4.12E−03	5.1
d-Myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis	4.12E−03	5.1
Estrogen-mediated S-phase entry	5.13E−03	12.5
3-phosphoinositide degradation	6.98E−03	4.7
EIF2 signaling				3.20E−04	5.7
Systemic lupus erythematosus signaling				6.10E−03	4.8
Oxidative phosphorylation				7.43E−03	6.1
Superoxide radicals degradation				7.94E−03	25.0
TNFR2 signaling				1.25E−02	10.7
Top networks related to diseases and functions
Cell cycle, DNA replication, recombination, and repair, cellular assembly and organization			44
Connective tissue disorders, developmental disorder, gastrointestinal disease			39
Cellular assembly and organization, inflammatory disease, inflammatory response			37
Cancer, cell death and survival, organismal injury and abnormalities						51
Hereditary disorder, neurological disease, organismal injury and abnormalities						48
Carbohydrate metabolism, drug metabolism, molecular transport						41

ISSN: 1479-5876