Fig. 1

NSG mice reconstituted with PBMC from UC donors develop UC like symptoms and phenotype upon challenge with ethanol. A Macrophotographs of colons at autopsy of NSG-UC mice. a Unchallenged control group (control). b Group challenged with 10% ethanol at day 8, and 50% ethanol at days 15 and 18 (ethanol). B Photomicrographs of H&E-stained sections of distal parts of the colon from mice that had been challenged a control, b ethanol. Arrow indicates edema and influx of inflammatory cells. C Clinical- and histological score of control and ethanol challenged mice that had been challenged as described in A depicted as boxplot diagrams. Boxes represent upper and lower quartiles. Whiskers represent variability and outliers are plotted as individual points. Sample sizes: clinical activity score control n = 32, ethanol = 38; histological score: control n = 31, challenged n = 37. For comparison of unchallenged control group versus challenged group, a Student T-test was conducted