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Table 1 Hemodynamic data

From: R-100 improves pulmonary function and systemic fluid balance in sheep with combined smoke-inhalation injury and Pseudomonas aeruginosa sepsis

  BL 3 h 6 h 9 h 12 h 15 h 18 h 21 h 24 h
CO
 Control 5.37 ± 0.4 5.87 ± 0.59 5.76 ± 0.39 6.16 ± 0.44 5.93 ± 0.52 5.82 ± 0.47 6.19 ± 0.93 7.38 ± 0.65 7.53 ± 1.52
 R-100 5.58 ± 0.24 6.07 ± 0.26 6.16 ± 0.36 6.63 ± 0.41 6.99 ± 0.27 6.93 ± 0.26 6.81 ± 0.39 6.62 ± 0.41 6.63 ± 0.32
MAP
 Control 99 ± 1.8 106 ± 4.7 95 ± 6.5 88 ± 7.6 78 ± 9.6 74 ± 10.0 72 ± 10.7 81 ± 8.6 83 ± 7.9
 R-100 95 ± 3.2 99 ± 6.7 103 ± 9.5 98 ± 9.0 84 ± 9.5 76 ± 11.4 73 ± 11.9 85 ± 10.4 84 ± 6.9
HR
 Control 85 ± 2 97 ± 6 114 ± 6 116 ± 7 112 ± 8 115 ± 7 116 ± 8 123 ± 8 122 ± 13
 R-100 74 ± 3 109 ± 8 136 ± 11 136 ± 10 141 ± 9 134 ± 8 113 ± 8 116 ± 7 114 ± 7
PAP
 Control 19.5 ± 0.8 23.3 ± 0.4 23.7 ± 1.1 25.3 ± 0.5 26.0 ± 1.1 26.2 ± 1.4 27.8 ± 1.4 29.6 ± 0.7 30.2 ± 1.9*
 R-100 19.0 ± 0.5 19.8 ± 1.1 21.0 ± 1.4 22.4 ± 0.9 24.6 ± 0.7 24.0 ± 1.1 24.6 ± 0.7 25.4 ± 0.8 25.6 ± 1.0
PCWP
 Control 10.2 ± 0.7 14.3 ± 0.9 14.3 ± 1.0 15.8 ± .7 16.5 ± 0.6 16.2 ± 0.8 16.5 ± 0.9 17.0 ± 1.4 17.0 ± 2.0
 R-100 10.2 ± 0.5 13.2 ± 1.3 13.6 ± 1.4 14.4 ± 0.6 14.2 ± 0.4 13.6 ± 0.4 14.4 ± 0.6 15.0 ± .7 14.8 ± 0.7
CVP
 Control 5.8 ± 0.6 8.2 ± 0.8 9.0 ± 0.9 11.5 ± 1.0 11.3 ± 0.8 11.3 ± 0.5 12.0 ± 1.0 12.2 ± 1.7 11.2 ± 2.3
 R-100 5.8 ± 1.0 7.8 ± 1.0 7.8 ± 0.7 9.2 ± 0.5 9.2 ± 1.5 12.0 ± 0.8 13.0 ± 0.6 11.0 ± 0.5 10.8 ± 0.7
LAP
 Control 9.3 ± 0.4 9.8 ± 0.6 10.6 ± 1.0 13.4 ± 0.9 11.6 ± 0.7 12.0 ± 0.6 12.6 ± 1.3 14.8 ± 1.7 12.0 ± 2.9
 R-100 8.2 ± 0.4 9.0 ± 1.1 9.2 ± 0.9 11.2 ± 0.5 12.2 ± 0.6 12.4 ± 0.8 13.6 ± 0.7 12.8 ± 0.2 13.0 ± 0.3
SVI
 Control 70.0 ± 6.1 70.5 ± 11.9 57.4 ± 6.2 61.2 ± 8.3 60.2 ± 6.1 57.1 ± 5.5 60.0 ± 9.4 67.0 ± 7.7 69.0 ± 13.3
 R-100 84.0 ± 3.3 62.8 ± 5.7 50.5 ± 2.0 54.3 ± 3.5 55.3 ± 3.2 57.9 ± 3.2 67.1 ± 4.4 63.0 ± 1.7 64.5 ± 1.8
SVRI
 Control 1286 ± 93 1259 ± 135 1097 ± 125 922 ± 133 858 ± 166 812 ± 164 776 ± 164 727 ± 150 847 ± 222
 R-100 1159 ± 39 1093 ± 56 1134 ± 106 987 ± 124 779 ± 87 683 ± 130 645 ± 119 819 ± 105 798 ± 66
PVRI
 Control 128.0 ± 13.5 117.2 ± 16.5 120.9 ± 17.2 114.5 ± 127 117.7 ± 136 128.8 ± 247 160.9 ± 441 128.0 ± 19 153.0 ± 33
 R-100 115.8 ± 12.4 80.5 ± 11.6 87.2 ± 16.3 88.1 ± 6.6 108.2 ± 7.8 109.4 ± 11 110.0 ± 9.0 117.2 ± 6.4 119.1 ± 9.0
LVSWI
 Control 85.0 ± 8.1 90.6 ± 20.2 62.4 ± 8.1 59.4 ± 9.4 51.0 ± 9.3 43.7 ± 7.4 45.3 ± 10.2 57.0 ± 7.5 60.0 ± 10.8
 R-100 97.0 ± 6.8 73.9 ± 8.6 61.4 ± 5.6 61.1 ± 5.7 52.7 ± 7.4 48.5 ± 6.8 55.8 ± 13.9 61.2 ± 10.2 60.7 ± 6.4
RVSWI
 Control 12.9 ± 1.1 14.8 ± 2.9 11.3 ± 0.9 11.3 ± 1.2 12.2 ± 1.8 11.7 ± 1.7 12.3 ± 1.5 15.0 ± 1.2 17.0 ± 2.6
 R-100 15.0 ± 1.4 10.1 ± 1.0 9.0 ± 0.6 9.7 ± 0.7 11.7 ± 1.5 9.4 ± 1.3 10.8 ± 1.5 12.4 ± 1.0 13.1 ± 1.2
PaCO2
 Control 37.8 ± 0.9 25.6 ± 2.4 27.3 ± 2.4 26.4 ± 2.7 27.8 ± 1.8 26.7 ± 2.7 29.3 ± 2.5 26.6 ± 0.9 36.2 ± 2.6
 R-100 36.6 ± 1.2 25.4 ± 1.8 26.6 ± 2.9 27.4 ± 1.0 27.2 ± 1.0 27.0 ± 0.7 25.4 ± 1.6 29.6 ± 1.5 28.4 ± 2.5
SaO2
 Control 91.5 ± 0.3 91.6 ± 2.7 90.2 ± 1.2 90.3 ± 0.6 88.3 ± 1.0 88.4 ± 3.4 87.8 ± 2.6 89.2 ± 2.5 76.2 ± 6.8*
 R-100 91.4 ± 0.3 93.8 ± 0.3 90.0 ± 1.1 90.2 ± 0.8 89.6 ± 1.0 88.5 ± 1.3 90.3 ± 1.3 91.7 + 1.4 91.9 ± 0.5
PvO2
 Control 47.3 ± 2.8 47.0 ± 4.2 47.0 ± 4.0 47.8 ± 2.4 46.3 ± 3.5 53.2 ± 3.2 52.3 ± 4.5 54.8 ± 4.8 46.8 ± 6.4
 R-100 43.8 ± 2.4 54.4 ± 7.4 51.8 ± 5.3 51.0 ± 1.8 52.4 ± 4.2 52.8 ± 3.9 56.6 ± 2.5 58.0 ± 5.13 60.6 ± 3.5
PvCO2
 Control 44.5 ± 2.3 32.7 ± 2.7 32.5 ± 2.4 30.8 ± 3.3 30.7 ± 1.6 28.7 ± 1.9 32.5 ± 2.4 32.4 ± 1.3 41.2 ± 3.9
 R-100 41.4 ± 2.0 33.4 ± 3.3 30.2 ± 1.7 32.6 ± 1.2 31.4 ± 1.3 30.4 ± 1.3 30.6 ± 2.5 35.2 ± 3.3 30.8 ± 2.2
SvO2
 Control 63.6 ± 3.0 65.2 ± 4.6 63.9 ± 3.4 66.6 ± 2.0 63.8 ± 4.0 70.2 ± 4.9 68.9 ± 4.7 69.9 ± 2.7 50.7 ± 8.1
 R-100 61.4 ± 1.8 71.3 ± 2.2 67.9 ± 2.4 64.8 ± 3.7 67.0 ± 3.3 68.3 ± 3.2 71.0 ± 4.2 69.4 ± 3.8 72.3 ± 3.5
  1. Data are expressed as mean ± SEM
  2. * P < 0.05 vs. control
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