Table 1 Hemodynamic data
BL | 3 h | 6 h | 9 h | 12 h | 15 h | 18 h | 21 h | 24 h | |
|---|---|---|---|---|---|---|---|---|---|
CO | |||||||||
Control | 5.37 ± 0.4 | 5.87 ± 0.59 | 5.76 ± 0.39 | 6.16 ± 0.44 | 5.93 ± 0.52 | 5.82 ± 0.47 | 6.19 ± 0.93 | 7.38 ± 0.65 | 7.53 ± 1.52 |
R-100 | 5.58 ± 0.24 | 6.07 ± 0.26 | 6.16 ± 0.36 | 6.63 ± 0.41 | 6.99 ± 0.27 | 6.93 ± 0.26 | 6.81 ± 0.39 | 6.62 ± 0.41 | 6.63 ± 0.32 |
MAP | |||||||||
Control | 99 ± 1.8 | 106 ± 4.7 | 95 ± 6.5 | 88 ± 7.6 | 78 ± 9.6 | 74 ± 10.0 | 72 ± 10.7 | 81 ± 8.6 | 83 ± 7.9 |
R-100 | 95 ± 3.2 | 99 ± 6.7 | 103 ± 9.5 | 98 ± 9.0 | 84 ± 9.5 | 76 ± 11.4 | 73 ± 11.9 | 85 ± 10.4 | 84 ± 6.9 |
HR | |||||||||
Control | 85 ± 2 | 97 ± 6 | 114 ± 6 | 116 ± 7 | 112 ± 8 | 115 ± 7 | 116 ± 8 | 123 ± 8 | 122 ± 13 |
R-100 | 74 ± 3 | 109 ± 8 | 136 ± 11 | 136 ± 10 | 141 ± 9 | 134 ± 8 | 113 ± 8 | 116 ± 7 | 114 ± 7 |
PAP | |||||||||
Control | 19.5 ± 0.8 | 23.3 ± 0.4 | 23.7 ± 1.1 | 25.3 ± 0.5 | 26.0 ± 1.1 | 26.2 ± 1.4 | 27.8 ± 1.4 | 29.6 ± 0.7 | 30.2 ± 1.9* |
R-100 | 19.0 ± 0.5 | 19.8 ± 1.1 | 21.0 ± 1.4 | 22.4 ± 0.9 | 24.6 ± 0.7 | 24.0 ± 1.1 | 24.6 ± 0.7 | 25.4 ± 0.8 | 25.6 ± 1.0 |
PCWP | |||||||||
Control | 10.2 ± 0.7 | 14.3 ± 0.9 | 14.3 ± 1.0 | 15.8 ± .7 | 16.5 ± 0.6 | 16.2 ± 0.8 | 16.5 ± 0.9 | 17.0 ± 1.4 | 17.0 ± 2.0 |
R-100 | 10.2 ± 0.5 | 13.2 ± 1.3 | 13.6 ± 1.4 | 14.4 ± 0.6 | 14.2 ± 0.4 | 13.6 ± 0.4 | 14.4 ± 0.6 | 15.0 ± .7 | 14.8 ± 0.7 |
CVP | |||||||||
Control | 5.8 ± 0.6 | 8.2 ± 0.8 | 9.0 ± 0.9 | 11.5 ± 1.0 | 11.3 ± 0.8 | 11.3 ± 0.5 | 12.0 ± 1.0 | 12.2 ± 1.7 | 11.2 ± 2.3 |
R-100 | 5.8 ± 1.0 | 7.8 ± 1.0 | 7.8 ± 0.7 | 9.2 ± 0.5 | 9.2 ± 1.5 | 12.0 ± 0.8 | 13.0 ± 0.6 | 11.0 ± 0.5 | 10.8 ± 0.7 |
LAP | |||||||||
Control | 9.3 ± 0.4 | 9.8 ± 0.6 | 10.6 ± 1.0 | 13.4 ± 0.9 | 11.6 ± 0.7 | 12.0 ± 0.6 | 12.6 ± 1.3 | 14.8 ± 1.7 | 12.0 ± 2.9 |
R-100 | 8.2 ± 0.4 | 9.0 ± 1.1 | 9.2 ± 0.9 | 11.2 ± 0.5 | 12.2 ± 0.6 | 12.4 ± 0.8 | 13.6 ± 0.7 | 12.8 ± 0.2 | 13.0 ± 0.3 |
SVI | |||||||||
Control | 70.0 ± 6.1 | 70.5 ± 11.9 | 57.4 ± 6.2 | 61.2 ± 8.3 | 60.2 ± 6.1 | 57.1 ± 5.5 | 60.0 ± 9.4 | 67.0 ± 7.7 | 69.0 ± 13.3 |
R-100 | 84.0 ± 3.3 | 62.8 ± 5.7 | 50.5 ± 2.0 | 54.3 ± 3.5 | 55.3 ± 3.2 | 57.9 ± 3.2 | 67.1 ± 4.4 | 63.0 ± 1.7 | 64.5 ± 1.8 |
SVRI | |||||||||
Control | 1286 ± 93 | 1259 ± 135 | 1097 ± 125 | 922 ± 133 | 858 ± 166 | 812 ± 164 | 776 ± 164 | 727 ± 150 | 847 ± 222 |
R-100 | 1159 ± 39 | 1093 ± 56 | 1134 ± 106 | 987 ± 124 | 779 ± 87 | 683 ± 130 | 645 ± 119 | 819 ± 105 | 798 ± 66 |
PVRI | |||||||||
Control | 128.0 ± 13.5 | 117.2 ± 16.5 | 120.9 ± 17.2 | 114.5 ± 127 | 117.7 ± 136 | 128.8 ± 247 | 160.9 ± 441 | 128.0 ± 19 | 153.0 ± 33 |
R-100 | 115.8 ± 12.4 | 80.5 ± 11.6 | 87.2 ± 16.3 | 88.1 ± 6.6 | 108.2 ± 7.8 | 109.4 ± 11 | 110.0 ± 9.0 | 117.2 ± 6.4 | 119.1 ± 9.0 |
LVSWI | |||||||||
Control | 85.0 ± 8.1 | 90.6 ± 20.2 | 62.4 ± 8.1 | 59.4 ± 9.4 | 51.0 ± 9.3 | 43.7 ± 7.4 | 45.3 ± 10.2 | 57.0 ± 7.5 | 60.0 ± 10.8 |
R-100 | 97.0 ± 6.8 | 73.9 ± 8.6 | 61.4 ± 5.6 | 61.1 ± 5.7 | 52.7 ± 7.4 | 48.5 ± 6.8 | 55.8 ± 13.9 | 61.2 ± 10.2 | 60.7 ± 6.4 |
RVSWI | |||||||||
Control | 12.9 ± 1.1 | 14.8 ± 2.9 | 11.3 ± 0.9 | 11.3 ± 1.2 | 12.2 ± 1.8 | 11.7 ± 1.7 | 12.3 ± 1.5 | 15.0 ± 1.2 | 17.0 ± 2.6 |
R-100 | 15.0 ± 1.4 | 10.1 ± 1.0 | 9.0 ± 0.6 | 9.7 ± 0.7 | 11.7 ± 1.5 | 9.4 ± 1.3 | 10.8 ± 1.5 | 12.4 ± 1.0 | 13.1 ± 1.2 |
PaCO2 | |||||||||
Control | 37.8 ± 0.9 | 25.6 ± 2.4 | 27.3 ± 2.4 | 26.4 ± 2.7 | 27.8 ± 1.8 | 26.7 ± 2.7 | 29.3 ± 2.5 | 26.6 ± 0.9 | 36.2 ± 2.6 |
R-100 | 36.6 ± 1.2 | 25.4 ± 1.8 | 26.6 ± 2.9 | 27.4 ± 1.0 | 27.2 ± 1.0 | 27.0 ± 0.7 | 25.4 ± 1.6 | 29.6 ± 1.5 | 28.4 ± 2.5 |
SaO2 | |||||||||
Control | 91.5 ± 0.3 | 91.6 ± 2.7 | 90.2 ± 1.2 | 90.3 ± 0.6 | 88.3 ± 1.0 | 88.4 ± 3.4 | 87.8 ± 2.6 | 89.2 ± 2.5 | 76.2 ± 6.8* |
R-100 | 91.4 ± 0.3 | 93.8 ± 0.3 | 90.0 ± 1.1 | 90.2 ± 0.8 | 89.6 ± 1.0 | 88.5 ± 1.3 | 90.3 ± 1.3 | 91.7 + 1.4 | 91.9 ± 0.5 |
PvO2 | |||||||||
Control | 47.3 ± 2.8 | 47.0 ± 4.2 | 47.0 ± 4.0 | 47.8 ± 2.4 | 46.3 ± 3.5 | 53.2 ± 3.2 | 52.3 ± 4.5 | 54.8 ± 4.8 | 46.8 ± 6.4 |
R-100 | 43.8 ± 2.4 | 54.4 ± 7.4 | 51.8 ± 5.3 | 51.0 ± 1.8 | 52.4 ± 4.2 | 52.8 ± 3.9 | 56.6 ± 2.5 | 58.0 ± 5.13 | 60.6 ± 3.5 |
PvCO2 | |||||||||
Control | 44.5 ± 2.3 | 32.7 ± 2.7 | 32.5 ± 2.4 | 30.8 ± 3.3 | 30.7 ± 1.6 | 28.7 ± 1.9 | 32.5 ± 2.4 | 32.4 ± 1.3 | 41.2 ± 3.9 |
R-100 | 41.4 ± 2.0 | 33.4 ± 3.3 | 30.2 ± 1.7 | 32.6 ± 1.2 | 31.4 ± 1.3 | 30.4 ± 1.3 | 30.6 ± 2.5 | 35.2 ± 3.3 | 30.8 ± 2.2 |
SvO2 | |||||||||
Control | 63.6 ± 3.0 | 65.2 ± 4.6 | 63.9 ± 3.4 | 66.6 ± 2.0 | 63.8 ± 4.0 | 70.2 ± 4.9 | 68.9 ± 4.7 | 69.9 ± 2.7 | 50.7 ± 8.1 |
R-100 | 61.4 ± 1.8 | 71.3 ± 2.2 | 67.9 ± 2.4 | 64.8 ± 3.7 | 67.0 ± 3.3 | 68.3 ± 3.2 | 71.0 ± 4.2 | 69.4 ± 3.8 | 72.3 ± 3.5 |