| |
BL
|
3 h
|
6 h
|
9 h
|
12 h
|
15 h
|
18 h
|
21 h
|
24 h
|
|---|
|
CO
|
|
Control
|
5.37 ± 0.4
|
5.87 ± 0.59
|
5.76 ± 0.39
|
6.16 ± 0.44
|
5.93 ± 0.52
|
5.82 ± 0.47
|
6.19 ± 0.93
|
7.38 ± 0.65
|
7.53 ± 1.52
|
|
R-100
|
5.58 ± 0.24
|
6.07 ± 0.26
|
6.16 ± 0.36
|
6.63 ± 0.41
|
6.99 ± 0.27
|
6.93 ± 0.26
|
6.81 ± 0.39
|
6.62 ± 0.41
|
6.63 ± 0.32
|
|
MAP
|
|
Control
|
99 ± 1.8
|
106 ± 4.7
|
95 ± 6.5
|
88 ± 7.6
|
78 ± 9.6
|
74 ± 10.0
|
72 ± 10.7
|
81 ± 8.6
|
83 ± 7.9
|
|
R-100
|
95 ± 3.2
|
99 ± 6.7
|
103 ± 9.5
|
98 ± 9.0
|
84 ± 9.5
|
76 ± 11.4
|
73 ± 11.9
|
85 ± 10.4
|
84 ± 6.9
|
|
HR
|
|
Control
|
85 ± 2
|
97 ± 6
|
114 ± 6
|
116 ± 7
|
112 ± 8
|
115 ± 7
|
116 ± 8
|
123 ± 8
|
122 ± 13
|
|
R-100
|
74 ± 3
|
109 ± 8
|
136 ± 11
|
136 ± 10
|
141 ± 9
|
134 ± 8
|
113 ± 8
|
116 ± 7
|
114 ± 7
|
|
PAP
|
|
Control
|
19.5 ± 0.8
|
23.3 ± 0.4
|
23.7 ± 1.1
|
25.3 ± 0.5
|
26.0 ± 1.1
|
26.2 ± 1.4
|
27.8 ± 1.4
|
29.6 ± 0.7
|
30.2 ± 1.9*
|
|
R-100
|
19.0 ± 0.5
|
19.8 ± 1.1
|
21.0 ± 1.4
|
22.4 ± 0.9
|
24.6 ± 0.7
|
24.0 ± 1.1
|
24.6 ± 0.7
|
25.4 ± 0.8
|
25.6 ± 1.0
|
|
PCWP
|
|
Control
|
10.2 ± 0.7
|
14.3 ± 0.9
|
14.3 ± 1.0
|
15.8 ± .7
|
16.5 ± 0.6
|
16.2 ± 0.8
|
16.5 ± 0.9
|
17.0 ± 1.4
|
17.0 ± 2.0
|
|
R-100
|
10.2 ± 0.5
|
13.2 ± 1.3
|
13.6 ± 1.4
|
14.4 ± 0.6
|
14.2 ± 0.4
|
13.6 ± 0.4
|
14.4 ± 0.6
|
15.0 ± .7
|
14.8 ± 0.7
|
|
CVP
|
|
Control
|
5.8 ± 0.6
|
8.2 ± 0.8
|
9.0 ± 0.9
|
11.5 ± 1.0
|
11.3 ± 0.8
|
11.3 ± 0.5
|
12.0 ± 1.0
|
12.2 ± 1.7
|
11.2 ± 2.3
|
|
R-100
|
5.8 ± 1.0
|
7.8 ± 1.0
|
7.8 ± 0.7
|
9.2 ± 0.5
|
9.2 ± 1.5
|
12.0 ± 0.8
|
13.0 ± 0.6
|
11.0 ± 0.5
|
10.8 ± 0.7
|
|
LAP
|
|
Control
|
9.3 ± 0.4
|
9.8 ± 0.6
|
10.6 ± 1.0
|
13.4 ± 0.9
|
11.6 ± 0.7
|
12.0 ± 0.6
|
12.6 ± 1.3
|
14.8 ± 1.7
|
12.0 ± 2.9
|
|
R-100
|
8.2 ± 0.4
|
9.0 ± 1.1
|
9.2 ± 0.9
|
11.2 ± 0.5
|
12.2 ± 0.6
|
12.4 ± 0.8
|
13.6 ± 0.7
|
12.8 ± 0.2
|
13.0 ± 0.3
|
|
SVI
|
|
Control
|
70.0 ± 6.1
|
70.5 ± 11.9
|
57.4 ± 6.2
|
61.2 ± 8.3
|
60.2 ± 6.1
|
57.1 ± 5.5
|
60.0 ± 9.4
|
67.0 ± 7.7
|
69.0 ± 13.3
|
|
R-100
|
84.0 ± 3.3
|
62.8 ± 5.7
|
50.5 ± 2.0
|
54.3 ± 3.5
|
55.3 ± 3.2
|
57.9 ± 3.2
|
67.1 ± 4.4
|
63.0 ± 1.7
|
64.5 ± 1.8
|
|
SVRI
|
|
Control
|
1286 ± 93
|
1259 ± 135
|
1097 ± 125
|
922 ± 133
|
858 ± 166
|
812 ± 164
|
776 ± 164
|
727 ± 150
|
847 ± 222
|
|
R-100
|
1159 ± 39
|
1093 ± 56
|
1134 ± 106
|
987 ± 124
|
779 ± 87
|
683 ± 130
|
645 ± 119
|
819 ± 105
|
798 ± 66
|
|
PVRI
|
|
Control
|
128.0 ± 13.5
|
117.2 ± 16.5
|
120.9 ± 17.2
|
114.5 ± 127
|
117.7 ± 136
|
128.8 ± 247
|
160.9 ± 441
|
128.0 ± 19
|
153.0 ± 33
|
|
R-100
|
115.8 ± 12.4
|
80.5 ± 11.6
|
87.2 ± 16.3
|
88.1 ± 6.6
|
108.2 ± 7.8
|
109.4 ± 11
|
110.0 ± 9.0
|
117.2 ± 6.4
|
119.1 ± 9.0
|
|
LVSWI
|
|
Control
|
85.0 ± 8.1
|
90.6 ± 20.2
|
62.4 ± 8.1
|
59.4 ± 9.4
|
51.0 ± 9.3
|
43.7 ± 7.4
|
45.3 ± 10.2
|
57.0 ± 7.5
|
60.0 ± 10.8
|
|
R-100
|
97.0 ± 6.8
|
73.9 ± 8.6
|
61.4 ± 5.6
|
61.1 ± 5.7
|
52.7 ± 7.4
|
48.5 ± 6.8
|
55.8 ± 13.9
|
61.2 ± 10.2
|
60.7 ± 6.4
|
|
RVSWI
|
|
Control
|
12.9 ± 1.1
|
14.8 ± 2.9
|
11.3 ± 0.9
|
11.3 ± 1.2
|
12.2 ± 1.8
|
11.7 ± 1.7
|
12.3 ± 1.5
|
15.0 ± 1.2
|
17.0 ± 2.6
|
|
R-100
|
15.0 ± 1.4
|
10.1 ± 1.0
|
9.0 ± 0.6
|
9.7 ± 0.7
|
11.7 ± 1.5
|
9.4 ± 1.3
|
10.8 ± 1.5
|
12.4 ± 1.0
|
13.1 ± 1.2
|
|
PaCO2
|
|
Control
|
37.8 ± 0.9
|
25.6 ± 2.4
|
27.3 ± 2.4
|
26.4 ± 2.7
|
27.8 ± 1.8
|
26.7 ± 2.7
|
29.3 ± 2.5
|
26.6 ± 0.9
|
36.2 ± 2.6
|
|
R-100
|
36.6 ± 1.2
|
25.4 ± 1.8
|
26.6 ± 2.9
|
27.4 ± 1.0
|
27.2 ± 1.0
|
27.0 ± 0.7
|
25.4 ± 1.6
|
29.6 ± 1.5
|
28.4 ± 2.5
|
|
SaO2
|
|
Control
|
91.5 ± 0.3
|
91.6 ± 2.7
|
90.2 ± 1.2
|
90.3 ± 0.6
|
88.3 ± 1.0
|
88.4 ± 3.4
|
87.8 ± 2.6
|
89.2 ± 2.5
|
76.2 ± 6.8*
|
|
R-100
|
91.4 ± 0.3
|
93.8 ± 0.3
|
90.0 ± 1.1
|
90.2 ± 0.8
|
89.6 ± 1.0
|
88.5 ± 1.3
|
90.3 ± 1.3
|
91.7 + 1.4
|
91.9 ± 0.5
|
|
PvO2
|
|
Control
|
47.3 ± 2.8
|
47.0 ± 4.2
|
47.0 ± 4.0
|
47.8 ± 2.4
|
46.3 ± 3.5
|
53.2 ± 3.2
|
52.3 ± 4.5
|
54.8 ± 4.8
|
46.8 ± 6.4
|
|
R-100
|
43.8 ± 2.4
|
54.4 ± 7.4
|
51.8 ± 5.3
|
51.0 ± 1.8
|
52.4 ± 4.2
|
52.8 ± 3.9
|
56.6 ± 2.5
|
58.0 ± 5.13
|
60.6 ± 3.5
|
|
PvCO2
|
|
Control
|
44.5 ± 2.3
|
32.7 ± 2.7
|
32.5 ± 2.4
|
30.8 ± 3.3
|
30.7 ± 1.6
|
28.7 ± 1.9
|
32.5 ± 2.4
|
32.4 ± 1.3
|
41.2 ± 3.9
|
|
R-100
|
41.4 ± 2.0
|
33.4 ± 3.3
|
30.2 ± 1.7
|
32.6 ± 1.2
|
31.4 ± 1.3
|
30.4 ± 1.3
|
30.6 ± 2.5
|
35.2 ± 3.3
|
30.8 ± 2.2
|
|
SvO2
|
|
Control
|
63.6 ± 3.0
|
65.2 ± 4.6
|
63.9 ± 3.4
|
66.6 ± 2.0
|
63.8 ± 4.0
|
70.2 ± 4.9
|
68.9 ± 4.7
|
69.9 ± 2.7
|
50.7 ± 8.1
|
|
R-100
|
61.4 ± 1.8
|
71.3 ± 2.2
|
67.9 ± 2.4
|
64.8 ± 3.7
|
67.0 ± 3.3
|
68.3 ± 3.2
|
71.0 ± 4.2
|
69.4 ± 3.8
|
72.3 ± 3.5
|
- Data are expressed as mean ± SEM
- * P < 0.05 vs. control
