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Table 2 Comparison of T0 and T1 biomarker values

From: The impact of antiretroviral therapy on iron homeostasis and inflammation markers in HIV-infected patients with mild anemia

Variables

Median (min–max)

All patients (n = 18)

p value*

Median (min–max)

Group A (n = 10)

p value*

Median (min–max)

Group B (n = 8)

p value*

Median (min–max)

T0

p value**

Median (min–max)

T1

p value**

T0

T1

T0

T1

T0

T1

Group A

Group B

Group A

Group B

CD4+

410.00 (10.00–831.00)

566.00 (252.00–1026.00)

0.0305

410.00 (10.00–831.00)

672.50 (334.00–1026.00)

0.0078

429.50 (106.00–697.00)

550.50 (252.00–733.00)

0.9453

410.00 (10.00–831.00)

429.50 (106.00–697.00)

0.9626

672.50 (334.00–1026.00)

550.50 (252.00–733.00)

0.3154

CD8+

1036.00 (423.00–2063.00)

962.50 (234.00–3100.00)

0.0833

986.50 (550.00–1865.00)

970.50 (409.00–3100.00)

0.0781

1090.00 (423.00–2063.00)

854.00 (254.00–1859.00)

0.4609

986.50 (550.00–1865.00)

1090.00 (423.00–2063.00)

0.7984

970.50 (409.00–3100.00)

854.00 (254.00–1859.00)

0.5726

CD4+/CD8+

0.60 (0.00–1.10)

0.64 (0.16–1.97)

0.0032

0.60 (0.00–1.00)

0.70 (0.16–1.97)

0.0039

0.55 (0.20–1.10)

0.61 (0.22–1.38)

0.2500

0.60 (0.00–1.00)

0.55 (0.20–1.10)

0.8087

0.70 (0.16–1.97)

0.61 (0.22–1.38)

0.9654

Viremia

23,270.00 (25.00–863,800.00)

< 37.00

0.0005

34,657.00 (4146.00–135,000.00)

< 37.00

0.0039

12,350.00 (25.00–863,800.00)

< 37.00

0.0225

34,657.00 (4146.00–135,000.00)

12,350.00 (25.00–863,800.00)

0.1672

< 37.00

< 37.00

1.0000

Hemoglobin (g/dl)

12.35 (9.50–12.90)

13.25 (10.80–15.70)

0.0008

12.70 (10.90–12.90)

14.25 (13.20–15.70)

0.0020

11.85 (9.50–12.80)

11.95 (10.80–12.90)

0.3828

12.70 (10.90–12.90)

11.85 (9.50–12.80)

0.0895

14.25 (13.20–15.70)

11.95 (10.80–12.90)

0.0004

IL-6 (pg/ml)

5.74 (3.29–9.83)

4.58 (2.91–11.91)

0.8317

6.11 (3.73–9.83)

4.97 (3.49–11.91)

0.8457

4.52 (3.29–8.50)

4.23 (2.91–7.05)

1.0000

6.11 (3.73–9.83)

4.52 (3.29–8.50)

0.2743

4.97 (3.49–11.91)

4.23 (2.91–7.05)

0.2133

IL-8 (pg/ml)

11.00 (2.90–418.00)

2.90 (2.90–119.00)

0.0418

9.65 (2.90–60.00)

2.90 (2.90–23.00)

0.0756

19.50 (2.90–418.00)

16.00 (2.90–119.00)

0.3828

9.65 (2.90–60.00)

19.50 (2.90–418.00)

0.5333

2.90 (2.90–23.00)

16.00 (2.90–119.00)

0.0169

IL-18 (pg/ml)

335.50 (145.00–868.00)

228.50 (111.00–808.00)

0.0092

282.50 (145.00–466.00)

149.50 (119.00–808.00)

0.1235

428.00 (145.00–868.00)

348.00 (111.00–533.00)

0.0391

282.50 (145.00–466.00)

428.00 (145.00–868.00)

0.0618

149.50 (119.00–808.00)

348.00 (111.00–533.00)

0.0816

MIP-1-β (pg/ml)

175.50 (83.00–687.00)

183.00 (30.00–981.00)

0.6164

175.50 (113.00–286.00)

125.50 (30.00–981.00)

0.4922

176.00 (83.00–687.00)

192.00 (72.00–620.00)

0.9453

175.50 (113.00–286.00)

176.00 (83.00–687.00)

0.8937

125.50 (30.00–981.00)

192.00 (72.00–620.00)

0.4232

MCP-1 (pg/ml)

166.00 (43.50–606.00)

124.00 (43.50–288.00)

0.0097

160.00 (43.50–606.00)

116.50 (43.50–288.00)

0.0972

166.00 (93.00–489.00)

131.50 (43.50–167.00)

0.0360

160.00 (43.50–606.00)

166.00 (93.00–489.00)

0.8239

116.50 (43.50–288.00)

131.50 (43.50–167.00)

0.8570

IL-22 (pg/ml)

16.50 (8.00–70.00)

16.00 (4.00–28.00)

0.4936

14.00 (8.00–70.00)

13.00 (4.00–22.00)

0.4406

19.00 (9.00–33.00)

19.50 (11.00–28.00)

1.0000

14.00 (8.00–70.00)

19.00 (9.00–33.00)

0.1177

13.00 (4.00–22.00)

19.50 (11.00–28.00)

0.1085

Hepcidin (ng/ml)

2.06 (0.50–22.93)

2.67 (0.33–11.38)

0.8650

4.41 (0.50–22.93)

2.71 (0.33–11.38)

0.7695

1.84 (0.52–3.87)

2.46 (0.72–6.92)

0.5469

4.41 (0.50–22.93)

1.84 (0.52–3.87)

0.2301

2.71 (0.33–11.38)

2.46 (0.72–6.92)

0.3740

Ferritin (ng/ml)

171.00 (9.00–415.00)

90.00 (6.00–280.00)

0.0120

192.50 (9.00–415.00)

80.00 (6.00–220.00)

0.0488

149.00 (16.00–303.00)

9.50 (58.00–280.00)

0.1953

192.50 (9.00–415.00)

149.00 (16.00–303.00)

0.5148

80.00 (6.00–220.00)

9.50 (58.00–280.00)

0.5938

Hepcidin/ferritin

0.02 (0.01–0.06)

0.03 (0.01–0.15)

0.0539

0.03 (0.02–0.06)

0.05 (0.01–0.15)

0.0645

0.02 (0.01–0.04)

0.01 (0.01–0.07)

0.3828

0.03 (0.02–0.06)

0.02 (0.01–0.04)

0.2031

0.05 (0.01–0.15)

0.01 (0.01–0.07)

0.0545

Iron (µg/dl)

73.00 (32.00–112.00)

71.00 (24.00–160.00)

0.6790

54.00 (32.00–91.00)

71.00 (24.00–160.00)

0.2408

85.50 (42.00–112.00)

70.50 (42.00–156.00)

0.3828

54.00 (32.00–91.00)

85.50 (42.00–112.00)

0.0455

71.00 (24.00–160.00)

70.50 (42.00–156.00)

0.7618

Transferrin (mg/dl)

195.00 (122.00–269.00)

201.50 (133.00–311.00)

0.7403

203.00 (144.00–269.00)

115.50 (148.00–311.00)

0.5533

184.50 (122.00–230.00)

184.50 (133.00–225.00)

0.7260

203.00 (144.00–269.00)

184.50 (122.00–230.00)

0.3154

115.50 (148.00–311.00)

184.50 (133.00–225.00)

0.0619

Transferrin saturation (%)

23.89 (9.31–55.99)

29.83 (7.35–55.21)

0.5509

21.41 (9.31–28.52)

29.83 (7.35–45.25)

0.2754

34.28 (16.34–55.99)

30.02 (16.69–55.21)

0.6406

21.41 (9.31–28.52)

34.28 (16.34–55.99)

0.0085

29.83 (7.35–45.25)

30.02 (16.69–55.21)

0.6334

  1. Biomarker values were compared at T0 and T1 for all patients, patients of group A, patients of group B and patients of group A vs group B. Median values and minimum/maximum values are reported for each group. Wilcoxon rank sum test for paired samples (p value*) and Wilcoxon rank sum test for independent samples (p value**) were used for comparison. In italics p > 0.05
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Journal of Translational Medicine

ISSN: 1479-5876

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