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Table 2 Comparison of T0 and T1 biomarker values

From: The impact of antiretroviral therapy on iron homeostasis and inflammation markers in HIV-infected patients with mild anemia

Variables Median (min–max)
All patients (n = 18)
p value* Median (min–max)
Group A (n = 10)
p value* Median (min–max)
Group B (n = 8)
p value* Median (min–max)
T0
p value** Median (min–max)
T1
p value**
T0 T1 T0 T1 T0 T1 Group A Group B Group A Group B
CD4+ 410.00 (10.00–831.00) 566.00 (252.00–1026.00) 0.0305 410.00 (10.00–831.00) 672.50 (334.00–1026.00) 0.0078 429.50 (106.00–697.00) 550.50 (252.00–733.00) 0.9453 410.00 (10.00–831.00) 429.50 (106.00–697.00) 0.9626 672.50 (334.00–1026.00) 550.50 (252.00–733.00) 0.3154
CD8+ 1036.00 (423.00–2063.00) 962.50 (234.00–3100.00) 0.0833 986.50 (550.00–1865.00) 970.50 (409.00–3100.00) 0.0781 1090.00 (423.00–2063.00) 854.00 (254.00–1859.00) 0.4609 986.50 (550.00–1865.00) 1090.00 (423.00–2063.00) 0.7984 970.50 (409.00–3100.00) 854.00 (254.00–1859.00) 0.5726
CD4+/CD8+ 0.60 (0.00–1.10) 0.64 (0.16–1.97) 0.0032 0.60 (0.00–1.00) 0.70 (0.16–1.97) 0.0039 0.55 (0.20–1.10) 0.61 (0.22–1.38) 0.2500 0.60 (0.00–1.00) 0.55 (0.20–1.10) 0.8087 0.70 (0.16–1.97) 0.61 (0.22–1.38) 0.9654
Viremia 23,270.00 (25.00–863,800.00) < 37.00 0.0005 34,657.00 (4146.00–135,000.00) < 37.00 0.0039 12,350.00 (25.00–863,800.00) < 37.00 0.0225 34,657.00 (4146.00–135,000.00) 12,350.00 (25.00–863,800.00) 0.1672 < 37.00 < 37.00 1.0000
Hemoglobin (g/dl) 12.35 (9.50–12.90) 13.25 (10.80–15.70) 0.0008 12.70 (10.90–12.90) 14.25 (13.20–15.70) 0.0020 11.85 (9.50–12.80) 11.95 (10.80–12.90) 0.3828 12.70 (10.90–12.90) 11.85 (9.50–12.80) 0.0895 14.25 (13.20–15.70) 11.95 (10.80–12.90) 0.0004
IL-6 (pg/ml) 5.74 (3.29–9.83) 4.58 (2.91–11.91) 0.8317 6.11 (3.73–9.83) 4.97 (3.49–11.91) 0.8457 4.52 (3.29–8.50) 4.23 (2.91–7.05) 1.0000 6.11 (3.73–9.83) 4.52 (3.29–8.50) 0.2743 4.97 (3.49–11.91) 4.23 (2.91–7.05) 0.2133
IL-8 (pg/ml) 11.00 (2.90–418.00) 2.90 (2.90–119.00) 0.0418 9.65 (2.90–60.00) 2.90 (2.90–23.00) 0.0756 19.50 (2.90–418.00) 16.00 (2.90–119.00) 0.3828 9.65 (2.90–60.00) 19.50 (2.90–418.00) 0.5333 2.90 (2.90–23.00) 16.00 (2.90–119.00) 0.0169
IL-18 (pg/ml) 335.50 (145.00–868.00) 228.50 (111.00–808.00) 0.0092 282.50 (145.00–466.00) 149.50 (119.00–808.00) 0.1235 428.00 (145.00–868.00) 348.00 (111.00–533.00) 0.0391 282.50 (145.00–466.00) 428.00 (145.00–868.00) 0.0618 149.50 (119.00–808.00) 348.00 (111.00–533.00) 0.0816
MIP-1-β (pg/ml) 175.50 (83.00–687.00) 183.00 (30.00–981.00) 0.6164 175.50 (113.00–286.00) 125.50 (30.00–981.00) 0.4922 176.00 (83.00–687.00) 192.00 (72.00–620.00) 0.9453 175.50 (113.00–286.00) 176.00 (83.00–687.00) 0.8937 125.50 (30.00–981.00) 192.00 (72.00–620.00) 0.4232
MCP-1 (pg/ml) 166.00 (43.50–606.00) 124.00 (43.50–288.00) 0.0097 160.00 (43.50–606.00) 116.50 (43.50–288.00) 0.0972 166.00 (93.00–489.00) 131.50 (43.50–167.00) 0.0360 160.00 (43.50–606.00) 166.00 (93.00–489.00) 0.8239 116.50 (43.50–288.00) 131.50 (43.50–167.00) 0.8570
IL-22 (pg/ml) 16.50 (8.00–70.00) 16.00 (4.00–28.00) 0.4936 14.00 (8.00–70.00) 13.00 (4.00–22.00) 0.4406 19.00 (9.00–33.00) 19.50 (11.00–28.00) 1.0000 14.00 (8.00–70.00) 19.00 (9.00–33.00) 0.1177 13.00 (4.00–22.00) 19.50 (11.00–28.00) 0.1085
Hepcidin (ng/ml) 2.06 (0.50–22.93) 2.67 (0.33–11.38) 0.8650 4.41 (0.50–22.93) 2.71 (0.33–11.38) 0.7695 1.84 (0.52–3.87) 2.46 (0.72–6.92) 0.5469 4.41 (0.50–22.93) 1.84 (0.52–3.87) 0.2301 2.71 (0.33–11.38) 2.46 (0.72–6.92) 0.3740
Ferritin (ng/ml) 171.00 (9.00–415.00) 90.00 (6.00–280.00) 0.0120 192.50 (9.00–415.00) 80.00 (6.00–220.00) 0.0488 149.00 (16.00–303.00) 9.50 (58.00–280.00) 0.1953 192.50 (9.00–415.00) 149.00 (16.00–303.00) 0.5148 80.00 (6.00–220.00) 9.50 (58.00–280.00) 0.5938
Hepcidin/ferritin 0.02 (0.01–0.06) 0.03 (0.01–0.15) 0.0539 0.03 (0.02–0.06) 0.05 (0.01–0.15) 0.0645 0.02 (0.01–0.04) 0.01 (0.01–0.07) 0.3828 0.03 (0.02–0.06) 0.02 (0.01–0.04) 0.2031 0.05 (0.01–0.15) 0.01 (0.01–0.07) 0.0545
Iron (µg/dl) 73.00 (32.00–112.00) 71.00 (24.00–160.00) 0.6790 54.00 (32.00–91.00) 71.00 (24.00–160.00) 0.2408 85.50 (42.00–112.00) 70.50 (42.00–156.00) 0.3828 54.00 (32.00–91.00) 85.50 (42.00–112.00) 0.0455 71.00 (24.00–160.00) 70.50 (42.00–156.00) 0.7618
Transferrin (mg/dl) 195.00 (122.00–269.00) 201.50 (133.00–311.00) 0.7403 203.00 (144.00–269.00) 115.50 (148.00–311.00) 0.5533 184.50 (122.00–230.00) 184.50 (133.00–225.00) 0.7260 203.00 (144.00–269.00) 184.50 (122.00–230.00) 0.3154 115.50 (148.00–311.00) 184.50 (133.00–225.00) 0.0619
Transferrin saturation (%) 23.89 (9.31–55.99) 29.83 (7.35–55.21) 0.5509 21.41 (9.31–28.52) 29.83 (7.35–45.25) 0.2754 34.28 (16.34–55.99) 30.02 (16.69–55.21) 0.6406 21.41 (9.31–28.52) 34.28 (16.34–55.99) 0.0085 29.83 (7.35–45.25) 30.02 (16.69–55.21) 0.6334
  1. Biomarker values were compared at T0 and T1 for all patients, patients of group A, patients of group B and patients of group A vs group B. Median values and minimum/maximum values are reported for each group. Wilcoxon rank sum test for paired samples (p value*) and Wilcoxon rank sum test for independent samples (p value**) were used for comparison. In italics p > 0.05