Fig. 8

Schematic representation of the c-Myc/miR-200b-3p/PRDX2 regulatory loop. c-Myc inhibits miR-200b-3p expression, and miR-200b-3p suppresses PRDX2 protein level. In turn, on the one hand, miR-200b-3p reduces c-Myc protein level by disrupting T58 phosphorylation and S62 phosphorylation status of c-Myc protein via suppressing AKT2/GSK3β pathway. On the other hand, miR-200b-3p inhibits c-Myc expression by repressing the activity of wnt/β-cateinin pathway though directly suppressing PRDX2