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Table 3 Minor allele frequencies of investigated SNPs in general population (controls), as reported for IBD (IBD) and in the IBD cohort described here (cohort)

From: Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease

Treatment

SNP

MAF controls [31]

MAF IBD [31]

MAF cohort

IRGM

C

0.13

0.18

0.14

ATG16L1

T

0.48

0.40 [44]

0.57

NOD2

T, C, C

 

rs2066844

T

0.07

0.14

0.07

rs2066845

C

0.01

0.05

0.03

rs2066847

C

0.02

0.11

0.04

XBP1

C, protective

0.04

0.04

0.05

LRRK2/MUC19

T

0.02

0.03

0.03

CCR6

A

0.47

0.48

0.50

IL23R

G, protective

0.08

0.02

0.04

STAT3

T

0.42

0.41

0.38

NCF4

C

0.33

0.38 [31, 45, 46]

0.31

  1. MAF minor allele frequency, SNP single nucleotide polymorphism