Effects of a multi-strain probiotic supplement for 12 weeks in circulating endotoxin levels and cardiometabolic profiles of medication naïve T2DM patients: a randomized clinical trial

Table 3 Baseline correlations between endotoxin and various parameters

Parameters	ALL (N = 78)		Placebo (N = 39)		Probiotics (N = 39)
Parameters	R	p	R	p	R	p
Age (years)	− 0.06	0.64	− 0.13	0.48	− 0.16	0.40
Weight (kg)	− 0.11	0.38	0.00	0.99	− 0.03	0.86
BMI (kg/m²)	− 0.09	0.48	− 0.02	0.91	− 0.06	0.78
Waist-hip ratio	− 0.15	0.27	0.01	0.98	0.03	0.89
Systolic BP (mmHg)	0.25	0.05	0.16	0.40	0.21	0.28
Diastolic BP (mmHg)	0.27	0.03	0.25	0.19	0.10	0.59
Mean arterial pressure (MAP)	0.26	0.04	0.22	0.23	0.09	0.63
Glycemic profile
Glucose (mmol/l)	0.22	0.08	0.15	0.44	− 0.01	0.96
Insulin (uU/ml)	− 0.12	0.35	− 0.18	0.35	− 0.10	0.59
C-peptide (ng/ml)	0.05	0.67	− 0.21	0.27	− 0.04	0.84
HOMA-IR	0.01	0.92	− 0.11	0.56	− 0.11	0.57
Lipid profile
Triglycerides (mmol/l)	0.21	0.09	− 0.02	0.92	0.37	0.04
Total cholesterol (mmol/l)	0.19	0.14	0.09	0.64	0.28	0.13
HDL-cholesterol (mmol/l)	− 0.25	0.04	0.09	0.63	− 0.35	0.05
LDL-cholesterol (mmol/l)	0.14	0.27	− 0.03	0.88	0.23	0.22
Total/HDL cholesterol ratio	0.32	0.01	0.07	0.73	0.41	0.02

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