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Table 1 Correlation of the ICC clinicopathological features and TNM staging with PTHLH expression (related to Fig. 1)

From: Autocrine parathyroid hormone-like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK-ATF2-cyclinD1 signaling

Variable N PTHLH expression in ICC
(n = 108) (%)
χ2 p value
High (75) Low (33)
Age (years)
 ≤50 25 18 (72.0) 7 (28.0) 0.100 NS
 >50 83 57 (68.7) 26 (31.3)
Gender
 Female 43 33 (76.7) 10 (23.3) 1.794 NS
 Male 65 42 (64.6) 23 (35.4)   
Pathological differentiation
 I 8 5 (62.5) 3 (37.5) 7.236 0.027
 II 53 31 (58.5) 22 (41.5)   
 III 47 39 (83.0) 8 (17.0)   
Tumor size (cm)
 ≥5 71 49 (69.0) 22 (31.0) 0.018 NS
 <5 37 26 (70.3) 11 (29.7)   
Intrahepatic metastasis
 Yes 44 24 (54.5) 20 (45.5) 7.768 0.005
 No 64 51 (79.7) 13 (20.3)   
Distant metastasis
 Yes 5 4 (80.0) 1 (10.0) 0.275 NS
 No 103 71 (68.9) 32 (31.1)   
TNM
 I–II 72 24 (33.3) 48 (66.7) 1.544 NS
 III–IV 36 9 (25.0) 27 (75.0)   
  1. Italic values indicate significance of p value (p < 0.05)
  2. NS not significant between any groups
  3. Note: ICC patients were divided into PTHLH ‘High’ group and ‘Low’ group
  4. Abbreviations: ICC, Intrahepatic cholangiocarcinoma; Differences among variables were assessed by χ2 or Fisher’s exact χ2 test