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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Autocrine parathyroid hormone-like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK-ATF2-cyclinD1 signaling

Fig. 6

A model of the PTHLH/PTH1R-ATF2 negative-feedback loop. PTHLH/PTH1R signaling activated the expression and transcriptional activity of ATF2 via the ERK1/2 and JNK signaling pathways to promoted ICC cell growth, and ATF2 positively regulated CyclinD1 expression and negatively regulated PTHLH expression. Treatment with ERK1/2 and JNK signaling pathway inhibitors abolished ATF2 transcriptional activity

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