Polymorphisms at microRNA binding sites of Ara-C and anthracyclines-metabolic pathway genes are associated with outcome of acute myeloid leukemia patients

Table 7 Significant effects of poly-miRTS on RFS of AML patients by univariate and multivariate Cox regression analysis

Genotype	Mean ± SE (day)	P	HR (95% CI)	P ^a	HR (95% CI)^a
rs10786736
GG	925 ± 113		1.00 (reference)		1.00 (reference)
CC	892 ± 146	0.722	0.851 (0.350–2.070)	0.926	0.959 (0.393–2.342)
CG	1267 ± 10	0.032	0.523 (0.289–0.946)	0.026	0.507 (0.279–0.921)
CC+CG^b	1214 ± 99	0.050	0.577 (0.333–1.000)	0.049	0.574 (0.331–0.997)
CC+GG^c	912 ± 97	0.034	1.855 (1.047–3.287)	0.022	1.957 (1.101–3.478)
rs3734703
CC	1325 ± 96		1.00 (reference)		1.00 (reference)
AA	592 ± 157	0.000	4.257 (1.936–9.360)	0.000	4.615 (2.086–10.209)
CA	921 ± 123	0.014	2.158 (1.169–3.984)	0.032	1.955 (1.058–3.611)
AA+CA^b	815 ± 113	0.001	2.544 (1.446–4.478)	0.003	2.357 (1.337–4.155)
rs8139
TT	1088 ± 150		1.00 (reference)		1.00 (reference)
CC	834 ± 172	0.122	1.801 (0.855–3.796)	0.175	1.677 (0.794–3.541)
CT	1182 ± 100	0.482	0.789 (0.408–1.526)	0.249	0.673 (0.343–1.319)
CC/CT		0.015	2.282 (1.174–4.435)	0.007	2.537 (1.295–4.970)
TT+CT^d	1176 ± 86	0.018	2.105 (1.134–3.907)	0.015	2.172 (1.162–4.059)

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