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Table 7 Significant effects of poly-miRTS on RFS of AML patients by univariate and multivariate Cox regression analysis

From: Polymorphisms at microRNA binding sites of Ara-C and anthracyclines-metabolic pathway genes are associated with outcome of acute myeloid leukemia patients

Genotype Mean ± SE (day) P HR (95% CI) P a HR (95% CI)a
rs10786736
 GG 925 ± 113   1.00 (reference)   1.00 (reference)
 CC 892 ± 146 0.722 0.851 (0.350–2.070) 0.926 0.959 (0.393–2.342)
 CG 1267 ± 10 0.032 0.523 (0.289–0.946) 0.026 0.507 (0.279–0.921)
 CC+CGb 1214 ± 99 0.050 0.577 (0.333–1.000) 0.049 0.574 (0.331–0.997)
 CC+GGc 912 ± 97 0.034 1.855 (1.047–3.287) 0.022 1.957 (1.101–3.478)
rs3734703
 CC 1325 ± 96   1.00 (reference)   1.00 (reference)
 AA 592 ± 157 0.000 4.257 (1.936–9.360) 0.000 4.615 (2.086–10.209)
 CA 921 ± 123 0.014 2.158 (1.169–3.984) 0.032 1.955 (1.058–3.611)
 AA+CAb 815 ± 113 0.001 2.544 (1.446–4.478) 0.003 2.357 (1.337–4.155)
rs8139
 TT 1088 ± 150   1.00 (reference)   1.00 (reference)
 CC 834 ± 172 0.122 1.801 (0.855–3.796) 0.175 1.677 (0.794–3.541)
 CT 1182 ± 100 0.482 0.789 (0.408–1.526) 0.249 0.673 (0.343–1.319)
 CC/CT   0.015 2.282 (1.174–4.435) 0.007 2.537 (1.295–4.970)
 TT+CTd 1176 ± 86 0.018 2.105 (1.134–3.907) 0.015 2.172 (1.162–4.059)
  1. Italic values indicate statistical significance
  2. aAdjusted for risk stratifications
  3. bThe dominant model
  4. cThe overdominance model
  5. dThe recessive model
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Journal of Translational Medicine

ISSN: 1479-5876

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